Results 51 to 60 of about 762,161 (305)

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

open access: yesMolecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu   +10 more
wiley   +1 more source

Academic News

open access: yesAethiopica, 2013
In 1998, the Accademia Nazionale dei Lincei (Rome) unanimously elected Professor Edward Ullendorff to be its Foreign Fellow for the Class of Humanities.
Lanfranco Ricci
doaj   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

open access: yesMolecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak   +10 more
wiley   +1 more source

„Steaua Italiei” a revenit unor personalităţi din mediul academic

open access: yesPlural: History, Culture, Society, 2015
"Star of Italy" returned personalities from ...
Octavian Munteanu
doaj  

Emeri van Donzel Honoured

open access: yesAethiopica, 2012
Personalia
Editorial Team
doaj   +1 more source

The Background, Development and Problems of Public History in China Jiang Meng

open access: yes, 2018
This article traces the origins and development of public history in China, from its roots in historical memory in pre-modern times, through its role in shaping the nation in the period of modernization, to the emergence of histories of everyday life and
Meng, Jiang
core   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

open access: yesMolecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi   +7 more
wiley   +1 more source

International Award for Scholars in Ethiopian Studies

open access: yesAethiopica, 2012
Personalia
Editorial Team
doaj   +1 more source

Negotiating Public Participation through Dance and Drama Techniques: A Roundtable Discussion on the Challenges of Public History Work by the Isikhumbuzo Applied History Unit in South Africa

open access: yes, 2019
The Isikhumbuzo Applied History Unit (IAHU) of Rhodes University History Department specializes in innovative methodologies for bringing historical information closer to non-academic audiences.
Hellemann, Phemelo C. < Isikhumbuzo Applied History Unit, Rhodes University, Makhanda, South Africa>
core   +1 more source

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

open access: yesMolecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen   +14 more
wiley   +1 more source

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