Results 61 to 70 of about 762,161 (305)
Despre „aventura italiană” in Moldova
Plural: History, Culture, Society, 2015 About "Italian Adventure" in ...
Ludmila Kojușko
doaj
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Sovereign Court of Vasily III: Historical and Genealogical Research
Вестник Волгоградского государственного университета. Серия 4. История, регионоведение, международные отношения, 2017 The research is focused on the issues concerning personal and genealogical composition of the Sovereign court during the great reign of Vasily the Third (1505–1533).
Aleksandr L. Korzinin, Nikita V. Bashnin
doaj +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
About Problems and Prospects of Humanities and Humanitarian Education in Russia
Высшее образование в России, 2019 The article presents reflections on the problems and prospects of humanities and humanitarian education in Russia, taking into account the basic program documents of the Russian state in the field of science and education.
O. V. Vorobieva
doaj +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma
Molecular Oncology, EarlyView.Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski +10 more
wiley +1 more source
, 2019 A rapid increase in the availability of digitized archival resources of relevance to family historians together with increasing individual fascination with genealogical research led to the University of Tasmania introducing a fully online Diploma of ...
Harman, Kristyn
core +1 more source
Do history teachers in Lithuania need academic history and academic historians?
, 2021 The starting point of the article is the problem of whether the academic history and relations with its representatives – academic historians – is one of the foundations on which the subject knowledge and practice of Lithuanian history teachers is based.
Šermukšnytė, Rūta,
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Molecular Oncology, EarlyView.Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski +12 more
wiley +1 more source