Results 41 to 50 of about 3,824,378 (404)

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

ACADEMIC LIBRARIES [PDF]

, 2009
  +8 more sources

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Essential and core books for veterinary medicine

Journal of the Medical Library Association, 2018
Objectives:This study defined core and essential lists of recent, English-language veterinary medicine books using a data-driven methodology for potential use by a broad audience, including libraries that are building collections supporting veterinary ...
Heather K. Moberly, Jessica R. Page
doaj   +1 more source

Navigating new norms: a systematic review of factors for the development of effective digital tools in higher education

FEBS Open Bio, EarlyView.
What factors make for an effective digital learning tool in Higher Education? This systematic review identifies elements of a digital tool that published examples reveal to be features of an engaging and impactful digital tool. A systematic literature search yielded 25 research papers for analysis.
Akmal Arzeman, Jessica Haines, Connie Pritchard, Stephen Rutherford, Nigel Francis   +4 more
wiley   +1 more source

Power and Status (and Lack Thereof) in Academe: Academic Freedom and Academic Librarians

In the Library with the Lead Pipe, 2020
Academic librarians (AL) do not experience full academic freedom (AF) protections, and AF for AL is not well studied. We surveyed ALs, with over 600 responses. This article focuses on librarian faculty status and how it intersects with AF perceptions and
Danya Leebaw, Alexis Logsdon
doaj  

The application of the social model of disability and Wilson’s model of information behaviour towards effective service delivery for students with disabilities within an academic library context

Inkanyiso, 2019
This paper explores the applicability of the social model of disability and Wilson’s model of information seeking behaviour for effective service delivery to students with disabilities in the context of academic libraries.
Dorothy Eneya, B. J. Mostert
doaj   +1 more source

Electronic Security Systems in Academic Libraries: A Case Study of Three University Libraries in South-West Nigeria. [PDF]

, 2011
This study examines the effectiveness of electronic security systems in academic libraries with a focus on selected university libraries in South-West Nigeria.
Osayande, Odaro
core   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Implications for academic libraries [PDF]

, 1975
This paper may present a more restricted view of the academic library interface with collective bargaining than might have been anticipated, primarily for three reasons.
Beckman, Margaret
core