Results 241 to 250 of about 1,980,638 (303)

Tetrastigma Hemsleyanum Polysaccharide Suppresses Triple‐Negative Breast Cancer by Disrupting the Hippo‐YAP/TEAD4‐PDIA4 Axis and Endoplasmic Reticulum Stress Adaptation

Advanced Science, EarlyView.
ABSTRACT Triple‐negative breast cancer (TNBC) exhibits addiction to chronic endoplasmic reticulum (ER) stress, which sustains an aggressive metastatic phenotype through activation of the unfolded protein response (UPR). Here, we identify a previously unrecognized “ER‐stress addiction” axis in which the Hippo pathway effector TEAD4 directly ...
Yini Shang, Wentao Si, Youxue Zhang, Jialin Liu, Huaixi Zhang, Yafei Li, Hongmeng Su, Wei Jiang, Zhishan Ding, Lihong Wang   +9 more
wiley   +1 more source

Reduced Maintenance DNA Methylation Thresholds Enable Sensitive Reporter Assays for UHRF1 and DNMT1 Inhibition

Advanced Science, EarlyView.
The authors engineer colorectal cancer cells with reduced redundancy of UHRF1 and DNMT1, key DNA methylation maintenance factors, lowering the maintenance threshold and sensitizing cells to inhibition. They develop reporter assays driven by endogenous tumor‐suppressor gene promoters with enhanced sensitivity and dynamic range to demethylating drugs ...
Cuicui Xia, Ying Cui, Jiongliang Wang, Wenjing Bai, Danyang Wang, Yao Chen, Huahui Guo, Liangyi Zong, Bing Qin, Xintong Cai, Jie Wang, Jing Huang, Scott B. Rothbart, Zufeng Guo, Stephen B. Baylin, Xiangqian Kong   +15 more
wiley   +1 more source

Correction: Understanding acceptance and resistance toward generative AI technologies: a multi-theoretical framework integrating functional, risk, and sociolegal factors. [PDF]

Front Artif Intell
Shrivastava P.
europepmc   +1 more source

Activation of ERBB4 Pathway Inhibits Pathological Transdifferentiation of Lung Epithelial Progenitors into CD66c+ Basal Cells in Severe Lung Injury

Advanced Science, EarlyView.
In fibrotic distal lung regions, CD66c+ basal cells emerge as a pathological state. Using human distal lung organoids, this study identifies CD66c+ basal cells as a pro‐fibrotic state arising through transdifferentiation from secretory, AT2, and basal cells.
Kaijun Lin, Xinran Deng, Haonan Wang, Yamei Jiang, Jian Sun, Hailin Ding, Ming Ye, Xiaoting Wang, Yu Wang, Li Yuan, Zhenju Song, Xinhua Lin, Shenfei Sun, Ning Jiang   +13 more
wiley   +1 more source

A data portrait-based approach to precision education for medical students in China. [PDF]

Medicine (Baltimore)
Yu S, Ju X, Ling C.
europepmc   +1 more source

Compassion in Balance: A Cross-Sectional Study on Satisfaction and Fatigue Among Clinical Nurses at HMC. [PDF]

Health Sci Rep
Patil SK, Rai R, Al-Lenjawi BA, Patil K, Singh K.   +4 more
europepmc   +1 more source

Academic Library Buildings

College & Research Libraries News, 1968
openaire   +2 more sources

ConNIS and labeling instability: New statistical methods for improving the detection of essential genes in TraDIS libraries. [PDF]

PLoS Comput Biol
Hanke M, Harten T, Foraita R.
europepmc   +1 more source

Perceived Stress and Psychological Distress in Prosthodontic Residents: A Systematic Review and Critical Appraisal of Evidence Gaps in Occupational Burnout. [PDF]

Cureus
Anbarasi K, Saravanakumar P, Kuzhanchinathan M, Rajkumar M, Haridoss S, Swaminathan K.   +5 more
europepmc   +1 more source

Partnering with rural libraries to increase telehealth utilization in New York state. [PDF]

J Med Libr Assoc
Gudina AT, Merritt S, Dhawan R, Insalaco ME, Kochanek J, Sackett M, Wicksall S, Wyckoff L, Huussen D, Cartujano-Barrera F, Cupertino AP, Foster M, Coleman J, Kamen CS.   +13 more
europepmc   +1 more source