Results 161 to 170 of about 589,411 (257)

Psychoeducational Challenges of Dyslexic Children During the COVID-19 Pandemic: A Systematic Review. [PDF]

Dyslexia
Ghasemi SA, SalarSadeghi M, Miri M, Khamesan A.   +3 more
europepmc   +1 more source

STWave: Fine‐Scale Spatial Structure Discovery in Microscopic‐Resolution Spatial Transcriptomics via Patchwise Wavelet Graphs

Advanced Science, EarlyView.
STWave transforms massive microscopic‐resolution spatial transcriptomics into interpretable fine‐scale tissue maps through patch‐wise inference, wavelet‐based multi‐scale encoding, and dual‐domain reconstruction. It reduces noise while preserving weak spatial signals, enabling efficient analysis of 6 40 000 spots of 2.47 GB GPU memory and revealing ...
Tao Jiang, Songming Zhang, Xiaofeng Chen, Xiongtao Xiao, Wenming Cao, Weikai Li, Tong Zhao, Bing Li, Xinyue Xu, Zhongshan Li   +9 more
wiley   +1 more source

Overcoming Drug Resistance by Paclitaxel Resistance in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
In the murine triple‐negative breast cancer (TNBC) model, chemotherapy effectively increases tumor neoantigen burden (TNB). Here, the study constructs a liposomal nanovaccine using antigens derived from in vitro chemotherapy‐treated paclitaxel‐resistant TNBC 4T1 cells.
Bo Chen, Yangyi Wang, Tingting Li, Changqing Guo, Zhe Xie, Zhixian Zhang, Xinghua Han, Wei Wang, Jian Wang, Xiaopeng Ma, Yuanzeng Min   +10 more
wiley   +1 more source

Screen use, health status, and self-perceived academic performance among Swedish dental and nursing students: an exploratory cross-sectional survey study. [PDF]

BMC Med Educ
Christidis N, Lärfars M, Khattar P, Markus D, Canales GT, Christidis M.   +5 more
europepmc   +1 more source

Uncoupling Type I Interferon Benefits From Inflammatory Toxicity: Transformer‐Prioritized Precision Agonists for Potent and Safer Cancer Immunotherapy

Advanced Science, EarlyView.
A Transformer‐based AI framework, DLINP, screens millions of compounds to identify Co68, a cobalt‐pincer organometallic complex that biases TLR4‐MD2 signaling toward antitumor interferon activation while suppressing inflammatory toxicity through an early TLR4‐SYK‐STAT1 axis.
Xuefei Guo, Yang Zhao, Xianle Rong, Xingyu Chen, Xiao Wang, Tianyi Liu, Yunfei Xie, Yushu Zou, Pingsen Zhao, Qiang Liu, Fuping You   +10 more
wiley   +1 more source

Is Wushu participation associated with internalizing problem behaviors among Chinese adolescents? A cross-sectional baseline survey. [PDF]

Front Public Health
Yang M, Ge X, Zhang D.
europepmc   +1 more source

Switching Spike Plasticity Shapes ACE2 Engagement Across SARS‐CoV‐2 Variants

Advanced Science, EarlyView.
Conformational plasticity governs SARS‐CoV‐2 spike function and ACE2 recognition. Using high‐speed AFM and single‐molecule force spectroscopy, we analyzed the ancestral spike and nine variants, revealing progressive rigidification from Delta, variable plasticity in Omicron sublineages, and JN.1 compaction.
Sarah Stainer, Rong Zhu, Manuel Reithofer, Gerhard Stadlmayr, Katharina Stadlbauer, Panchika Prangkio, Christoph Rippel, Markus Hahn, Aniko Eva Kasztner, Stefanie Stohl, Petr Bednar, Daniel Ruzek, David Glück, Robert Tampé, Gordana Wozniak‐Knopp, Yoo Jin Oh, Miriam Klausberger, Peter Hinterdorfer   +17 more
wiley   +1 more source

Sleep and the Developing Brain: What We Know, What We Don't, and Where to Act-A Systematic Review and Evidence and Gap Map. [PDF]

Eur J Investig Health Psychol Educ
Shonbay K, Shikhova OM, Duplyakin Y, Sagimova RS, Taushanova M, Karibayeva I.   +5 more
europepmc   +1 more source

Supramolecular Degraders: An Emerging Paradigm in Targeted Protein Degradation

Advanced Science, EarlyView.
Dynamic supramolecular assembly reshapes targeted protein degradation by coordinating modular degrader construction, delivery, functional integration, and intracellular assembly or activation across proteasomal, endosomal–lysosomal, and autophagy–lysosomal pathways.
Kongjun Liu, Xue Yuan, Yan Zhou, Rui Yuan, Shaocheng Xie, Yong Chen, Peiyi Wang, Jianmei Gao, Qihai Gong   +8 more
wiley   +1 more source

Cavity‐Enhanced Eye‐Readable Detection of 0.1% H2 via Active Modulation of Charge‐Transfer Plasmons

Advanced Science, EarlyView.
A cavity‐structured nanoparticle sensor is developed for highly sensitive, eye‐readable hydrogen detection. Its excellent colorimetric response arises from a hydrogen‐induced charge‐transfer mechanism: reduction of the dielectric oxide shell in H2 triggers a transition from the plasmonic gap mode to the charge‐transfer plasmon mode.
Xuemin Zhang, Shunsheng Ye, Lubing Cai, Chao Li, Zheng Cai, Jin Zhang, Fei Liu, Tieqiang Wang, Boxin Wei, Hongbo Zeng   +9 more
wiley   +1 more source