Results 41 to 50 of about 10,737 (305)
FEBS Letters, EarlyView.The pyruvate generator, which causes activation of respiration by extra‐mitochondrial Ca2+, is also present and functional in rat brainstem mitochondria, as it is in other brain regions. This finding is confirmed by experiments with a fully reconstituted malate–aspartate shuttle (MAS).
Grazyna Debska‐Vielhaber +7 more
wiley +1 more source
Turkey’s Caucasus Policies, 2000-2022
, 2023 The emergence of newly independent states in the Caucasus at the end of the Cold War presented challenges to Turkey while enlarging its role. The collapse of the Soviet Union removed the century-old Sovi-et/Russian threat, simultaneously creating a power
Aydın, Mustafa, Aydın,M.
core +1 more source
Ubiquitination of secretory granules promotes their crinophagic degradation in Drosophila
FEBS Letters, EarlyView.Ubiquitination of secretory granules in Drosophila larval salivary glands is a critical molecular trigger for crinophagy, the lysosomal degradation of unreleased, or low‐quality granules. The E3 ubiquitin ligase Cnot4 is recruited to the surface of secretory granules to induce crinophagy.
Tamás Csizmadia +6 more
wiley +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source
Enhancing learning in the IS academies
, 2013 This research brief describes current mechanisms for learning in so-called ‘IS Academies’, collaborative projects of the Dutch Ministry of Foreign Affairs (MFA), academic institutes, and development agencies.
Hilhorst, Thea; id_orcid, van Delft, P
core +1 more source
CONSIDERATIONS REGARDIND THE SCIENTIFIC GROUNDS FOR SETTING UP SECURITY STRATEGIES [PDF]
Annals: Series on Military Sciences, 2016 The main objective of the paper is to present a point of view on scientific approaches towards the security strategy so as to create opportunities to intensify the exchange of scientific ideas between scientists.
Mihai ILIESCU, Eugen SITEANU
doaj
Mathematical Instruments Used in the Military Engineering Academies of the Ottomans
, 2018 6th IFToMM International Symposium on the History of Machines and Mechanisms (HMM) -- SEP 26-28, 2018 -- Chinese Acad Sci, Inst Hist Nat Sci, Beijing, PEOPLES R CHINAAt the end of 17th century and during 18th century, in order to train elite cadets who ...
Irem Aslan Seyhan, Seyhan, Irem Asian
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Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source