Results 111 to 120 of about 1,985,761 (312)

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

A qualitative exploration of community knowledge, attitudes, and practices towards tuberculosis in the Karamoja subregion, northeastern Uganda

BMC Health Services Research
Background The Karamoja subregion is a high TB burden pastoralist community that previously had limited access to public health services. We explored the community’s perceptions towards TB to better understand how healthcare services should be structured
William Kasozi, Stella Zawedde-Muyanja, Joseph Musaazi, Alfred Etwom, James Lemukol, Patrick Sagaki, Salome Tino, Cerino Achar, Mary G. Nabukenya-Mudiope, Turyahabwe Stavia, Miriam Murungi, Edmund Rutta, Tadeo Nsubuga, Brenda Picho   +13 more
doaj   +1 more source

Does Fatigue Alter Pitching Mechanics?

Orthopaedic Journal of Sports Medicine, 2016
Objectives: Background: Injuries of the adolescent shoulder and elbow are common in baseball pitchers. Fatigue has been demonstrated to be a risk factor for injury.
Peter Nissen Chalmers MD, Brandon J. Erickson, Terrance Sgroi DPT, Peter Vignona, Matthew Lesniak DPT, Charles A. Bush-Joseph MD, Nikhil N. Verma MD, Anthony A. Romeo MD   +7 more
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Postsecondary Pathways Out of Poverty: City University of New York Accelerated Study in Associate Programs and the Case for National Policy

RSF: The Russell Sage Foundation Journal of the Social Sciences, 2018
A postsecondary education holds the promise of higher lifetime earnings and social mobility, but too many low-income students never complete their degrees.
Diana Strumbos, Donna Linderman, Carson C. Hicks   +2 more
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Dynamic damage analysis of carbon fiber reinforced polymer composite pressure vessels

Fracture and Structural Integrity
This study investigates spall damage and failure in Carbon Fiber-Reinforced Polymer (CFRP) pressure vessels under explosive internal loading using stimulated electric discharge.
Kamal M. Hammad, Iuliia A. Sadykova, Eugene N. Prokopev, Galina V. Tyurina, Semen D. Ignatyev, Eugene S. Statnik   +5 more
doaj   +3 more sources

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source