Results 61 to 70 of about 2,166,464 (300)

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Accelerated Linearized Bregman Method [PDF]

, 2011
In this paper, we propose and analyze an accelerated linearized Bregman (ALB) method for solving the basis pursuit and related sparse optimization problems.
Goldfarb, Donald, Huang, Bo, Ma, Shiqian
core   +1 more source

Radiation from Accelerated Branes

, 2000
The radiation emitted by accelerated fundamental strings and D-branes is studied within the linear approximation to the supergravity limit of string theory.
A. Dabholkar, A. Hashimoto, A. Vilenkin, C. Bachas, C. M. Hull, C. P. Bachas, E. Witten, E. Witten, G. Horowitz, I. R. Klebanov, J. D. Jackson, J. H. Schwarz, J. H. Schwarz, J. L. F. Barbón, J. Maharana, J. Maldacena, J. Polchinski, J. Polchinski, L. D. Landau, M. B. Green, M. B. Green, M. R. Douglas, M. R. Douglas, M. R. Garousi, Miguel S. Costa, Mohab Abou-Zeid, P. K. Townsend, R. Dijkgraaf, R. Dijkgraaf, R. Dijkgraaf, S. R. Das, S. R. Das, S. S. Gubser, S. S. Gubser, S. Weinberg, V. P. Frolov, V. Periwal, V. Periwal, W. Fischler   +38 more
core   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Weak decay of uniformly accelerated protons and related processes

, 2000
We investigate the weak interaction emission of spin-1/2 fermions from accelerated currents. As particular applications, we analyze the decay of uniformly accelerated protons and neutrons, and the neutrino-antineutrino emission from uniformly accelerated
A. D. Kaminker, A. D. Kaminker, A. I. Nikishov, A. Vidaurre, C. Caso, Daniel A. T. Vanzella, G. E. A. Matsas, George E. A. Matsas, I. S. Gradshteyn, J. D. Jackson, J. D. Landstreet, L. B. Leinson, L. C. B. Crispino, N. D. Birrell, P. C. W. Davies, R. Muller, S. A. Fulling, S. Takagi, V. B. Berestetskii, V. L. Ginzburg, V. N. Baier, V. N. Baier, W. G. Unruh   +22 more
core   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

A Variational Perspective on Accelerated Methods in Optimization

, 2016
Accelerated gradient methods play a central role in optimization, achieving optimal rates in many settings. While many generalizations and extensions of Nesterov's original acceleration method have been proposed, it is not yet clear what is the natural ...
Jordan, Michael I., Wibisono, Andre, Wilson, Ashia C.   +2 more
core   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Accelerated rare event sampling

, 2015
A sampling procedure for the transition matrix Monte Carlo method is introduced that generates the density of states function over a wide parameter range with minimal coding effort.Comment: 7 pages 7 ...
Yevick, David
core   +1 more source