Results 71 to 80 of about 2,166,464 (300)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Underlying factors determining grain morphologies in high-strength titanium alloys processed by additive manufacturing

Nature Communications, 2023
In recent research, additions of solute to Ti and some Ti-based alloys have been employed to produce equiaxed microstructures when processing these materials using additive manufacturing.
Mohan S. K. K. Y. Nartu, Brian A. Welk, Srinivas A. Mantri, Nevin L. Taylor, Gopal B. Viswanathan, Narendra B. Dahotre, Rajarshi Banerjee, Hamish L. Fraser   +7 more
doaj   +1 more source

Directed Accelerated Growth: Application in Citation Network

, 2004
In many real world networks, the number of links increases nonlinearly with the number of nodes. Models of such accelerated growth have been considered earlier with deterministic and stochastic number of links.
Albert, Barabási, Barabási, Broder, Dorogovtsev, Dorogovtsev, Dorogovtsev, Faloutsos, Ferrar, Jeong, Krapivsky, Laherrere, Liu, Parongama Sen, Redner, Sen, Tadic, van Nimwegen   +17 more
core   +2 more sources

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Future Accelerators [PDF]

AIP Conference Proceedings, 2004
I describe the future accelerator facilities that are currently foreseen for electroweak scale physics, neutrino physics, and nuclear structure. I will explore the physics justification for these machines, and suggest how the case for future accelerators can be made.
openaire   +2 more sources

Scattering of accelerated wave packets [PDF]

, 2018
Wave-packet scattering from a stationary potential is significantly modified when the wave-packet is subject to an external time-dependent force during the interaction.
Della Valle, G., Horsley, S. A. R., Longhi, S.   +2 more
core   +2 more sources

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Case Report: Application of accelerated continuous theta burst stimulation in treatment-resistant depression

Frontiers in Psychiatry
Treatment-resistant depression (TRD) poses a significant challenge in psychiatric practice. While repetitive transcranial magnetic stimulation (rTMS) has emerged as a promising non-invasive neuromodulation technique for TRD, a subset of patients fails to
Guilan Sun, Zhongxia Shen, Minmin Wang, Xiaomei Zhang   +3 more
doaj   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Surveying New Testament survey: The impact of demographics and modality on an introductory New Testament course

Journal of the Scholarship of Teaching and Learning, 2014
Both adult and traditional students at Indiana Wesleyan University take an introductory New Testament course in conventional, compressed, and accelerated formats and through online and onsite settings.
Bart B. Bruehler
doaj   +1 more source