Results 131 to 140 of about 9,474,361 (376)

Protective role of female gender in programmed accelerated renal aging in the rat [PDF]

, 2015
The aging kidney exhibits a progressive decline in glomerular filtration rate, accompanied by inflammatory and oxidative damage. We hypothesized that accelerated, age-related progression of renal injury is ovarian hormones-dependant.
Antus, Attia, August, Baiardi, Baylis, Baylis, Baylis, Baylis, Birn, Bongartz, Bongartz, Botev, Colen, Corman, Cornock, Crofton, Dendooven, Elliot, Everitt, Gerondakis, Gerritsen, Gorriz, Hinton, Joles, Joles, Joles, Jung, Koeners, Langley, Langley-Evans, Langley-Evans, Langley-Evans, Lowry, Macova, Mazairac, McGrath, McMullen, McMullen, McMullen, Miyata, Poggio, Potier, Roesch, Rule, Sahajpal, Sahajpal, Sasser, Schreuder, Sherman, Sherman, Swali, Vanhaesebroeck, Vazquez, Wegorzewska, Wiggins, Woods, Wyndham, Yin, Zheng   +58 more
core   +3 more sources

Pathogenic Neurofibromatosis type 1 gene variants in tumors of non‐NF1 patients and role of R1276

FEBS Open Bio, EarlyView.
Somatic variants of the neurofibromatosis type 1 (NF1) gene occur across neoplasms without clinical manifestation of the disease NF1. We identified emerging somatic pathogenic NF1 variants and hotspots, for example, at the arginine finger 1276. Those missense variants provide fundamental information about neurofibromin's role in cancer.
Mareike Selig, Swanhild Lohse, Sara Elahi, Nils Hartmann, Stefanie Deckert, Shutian Si, Alexander Desuki, Anja Harder   +7 more
wiley   +1 more source

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

FEBS Open Bio, EarlyView.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl, Khawar Amin, Lydia Gabriel, Nils Hampel, Afshin Iram, Julia Hesse, Constanze Wiek, Jasmin Thuy Vy Nguyen, Helmut Hanenberg, Jürgen Scheller, M. Reza Ahmadian, Björn Stork, Doreen M. Floss, Roland P. Piekorz   +13 more
wiley   +1 more source

The relevance of α-KLOTHO to the central nervous system: Some key questions [PDF]

, 2017
α-Klotho is well described as an anti-aging protein, with critical roles in kidney function as a transmembrane co-receptor for FGF23, and as a soluble factor in serum.
Berwick, Daniel Charles, Cararo-Lopes, Marina Minto, Kawamoto, Elisa Mitiko, Mazucanti, Caio Henrique Yokoyama, Scavone, Cristoforo   +4 more
core   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Microwave-assisted synthesis of a MK2 inhibitor by Suzuki-Miyaura coupling for study in Werner syndrome cells [PDF]

, 2015
Microwave-assisted Suzuki-Miyaura cross-coupling reactions have been employed towards the synthesis of three different MAPKAPK2 (MK2) inhibitors to study accelerated aging in Werner syndrome (WS) cells, including the cross-coupling of a 2-chloroquinoline
Bagley, Mark C, Baashen, Mohammed, Chuckowree, Irina, Dwyer, Jessica E, Kipling, David, Davis, Terence   +5 more
core   +3 more sources

Enzymatic degradation of biopolymers in amorphous and molten states: mechanisms and applications

FEBS Open Bio, EarlyView.
This review explains how polymer morphology and thermal state shape enzymatic degradation pathways, comparing amorphous and molten biopolymer structures. By integrating structure–reactivity principles with insights from thermodynamics and enzyme engineering, it highlights mechanisms that enable efficient polymer breakdown.
Anđela Pustak, Aleksandra Maršavelski
wiley   +1 more source

Physiological and biochemical quality of paradise nut seed

Pesquisa Agropecuária Brasileira
The objective of this work was to evaluate the physiological quality of Lecythis pisonis seed and their biochemical changes after being subjected to accelerated aging.
Caroline Palacio de Araujo, Natasha Vieira de Oliveira, Thuanny Lins Monteiro, Ingridh Medeiros Simões, Joana Silva Costa, Débora Pellanda Fagundes, Edilson Romais Schmildt, José Carlos Lopes, Rodrigo Sobreira Alexandre   +8 more
doaj   +1 more source

Correlation between Sub-Tg relaxation processes and mechanical behavior for different hydrothermal ageing conditions in epoxy assemblies [PDF]

, 2010
The aim of this study is to understand aging phenomena by monitoring physical parameters after real and simulated aging experiments. This study focuses on aluminum-epoxy assemblies, which are commonly used on spacecraft structures.
Apicella, Bellenger, Bershtein, Boye, Cognard, Colombini, Comrie, Dodiuk, Gupta, Havriliak, Havriliak, Hedvig, Luo, Maggana, Mijovic, Moy, Nogueira, Ochi, Pangrle   +18 more
core   +2 more sources

Blood Biochemistry Analysis to Detect Smoking Status and Quantify Accelerated Aging in Smokers

Scientific Reports, 2019
There is an association between smoking and cancer, cardiovascular disease and all-cause mortality. However, currently, there are no affordable and informative tests for assessing the effects of smoking on the rate of biological aging.
Polina Mamoshina, Kirill Kochetov, Franco Cortese, Anna Kovalchuk, Alexander M. Aliper, E. Lane, M. Scheibye-Knudsen, Charles R. Cantor, N. Skjodt, O. Kovalchuk, A. Zhavoronkov   +10 more
semanticscholar   +1 more source