Results 131 to 140 of about 140,423 (257)

Effect of the JAK Inhibitor Baricitinib on Cytokine Production and Bone Properties in a Mouse Model of Accelerated Aging. [PDF]

Int J Mol Sci
Gelles K, Kurz V, Butylina M, Wahl-Figlash K, Schepelmann M, Meshcheryakova A, Pietschmann P.   +6 more
europepmc   +1 more source

Real‐World Longitudinal Data on the Impact of Hydroxychloroquine Blood Level Monitoring on Lupus Outcomes: Results of a Prospective Longitudinal Cohort Study

Arthritis Care &Research, EarlyView.
Objective Hydroxychloroquine (HCQ) is a cornerstone therapy in systemic lupus erythematosus (SLE), but the weight‐based dosing does not account for clinical factors that can introduce individual variability in drug metabolism and clearance. We leveraged longitudinal data from a prospective SLE cohort to identify clinical factors that predict ...
Jay J. Patel, Fauzia Hollangel, Caroline Packee, Amita Kapoor, Brad Rovin, Nathalie Costedoat‐Chalumeau, Shivani Garg   +6 more
wiley   +1 more source

Pregnancy as an Accelerated Aging Event: Reframing Maternal Risk Through Epigenetics. [PDF]

Obstet Gynecol
Williams Z, Suh Y.
europepmc   +1 more source

Obesity Subtypes and Longitudinal Trajectories of Function Over Seven Years of Follow‐Up: Data From the Multicenter Osteoarthritis Study

Arthritis Care &Research, EarlyView.
Objective Obesity, defined by body mass index (BMI) ≥30 kg/m2, is a risk factor for functional limitations in people with knee osteoarthritis (OA). However, function varies among such individuals. Our objective was to evaluate the implications of obesity subtypes on longitudinal patterns of physical functioning in people with or at risk for knee OA ...
Kristine Godziuk, Sarah Tilley, Michael LaValley, Michael C. Nevitt, Cora E. Lewis, James C. Torner, Tuhina Neogi, for the Multicenter Osteoarthritis Study Group   +7 more
wiley   +1 more source

Erratum: Placental epigenetic clocks derived from crowdsourcing: Implications for the study of accelerated aging in obstetrics. [PDF]

iScience
Bhatti G, Sufriyana H, Romero R, Patel T, Tekola-Ayele F, Alsaggaf I, Gomez-Lopez N, Su ECY, Done B, Hoffmann S, van Bömmel A, Wan C, Albrecht J, Novak C, DREAM Placenta Clock Challenge Consortium, Chaiworapongsa T, Sirota M, Aghaeepour N, Stolovitzky G, Bryant DR, Tarca AL.   +20 more
europepmc   +1 more source

Artificial Intelligence in Systemic Sclerosis: Clinical Applications, Challenges, and Future Directions

Arthritis Care &Research, EarlyView.
Systemic sclerosis (SSc) is a rare autoimmune disease defined by immune dysregulation, vasculopathy, and progressive fibrosis of the skin and internal organs. Despite advances in care, major complications such as interstitial lung disease (ILD) and myocardial involvement remain the leading causes of morbidity and mortality.
Cristiana Sieiro Santos, José Miguel Sequí‐Sabater, Diego Benavent   +2 more
wiley   +1 more source

Negative social ties as emerging risk factors for accelerated aging, inflammation, and multimorbidity. [PDF]

Proc Natl Acad Sci U S A
Lee B, Ciciurkaite G, Peng S, Mitchell C, Perry BL.   +4 more
europepmc   +1 more source

Clinical, Histologic, and Serological Predictors of Renal Function Loss in Lupus Nephritis

Arthritis Care &Research, EarlyView.
Objective Kidney survival is the ultimate goal in lupus nephritis (LN) management, but long‐term predictors remain inadequately studied, requiring long‐term follow‐up. This study aimed to identify baseline and early longitudinal predictors of kidney survival in the Accelerating Medicines Partnership LN longitudinal cohort.
Shangzhu Zhang, Laurence Magder, Daniel Goldman, Judith A. James, Joel M. Guthridge, Carla Guthridge, Peter Izmirly, Jill P. Buyon, H. Michael Belmont, Richard A. Furie, Noa Schwartz, Chaim Putterman, Jennifer L. Barnas, Jennifer H. Anolik, Sarah French, Maria Dall'Era, Avi Z. Rosenberg, Jeffrey Hodgin, Dawit S. Demeke, the Accelerating Medicines Partnership Rheumatoid Arthritis and Systemic Lupus Erythematosus (RA/SLE) Network, Michelle Petri, Andrea Fava   +21 more
wiley   +1 more source

Adipose single cell epigenome and transcriptome localize genetic risk for cardiometabolic disease and accelerated aging. [PDF]

Nat Commun
Lee SHT, Kar A, Gelev KZ, Chen ZJ, Das SS, Heinonen S, Saarinen T, Vaittinen M, Kaminska D, Peltoniemi H, Luo C, Juuti A, Männistö V, Pihlajamäki J, Kaikkonen MU, Pietiläinen KH, Balliu B, Pajukanta P.   +17 more
europepmc   +1 more source

Physician‐Scientist Pipeline for Pediatric Rheumatology: The Current Landscape and Future Perspectives

Arthritis Care &Research, EarlyView.
Over the past 50 years, the science of pediatric rheumatology has grown exponentially due to an expansion in the understanding of complex rheumatic conditions and a surge in novel targeted therapeutics. Physician‐scientists in the field of pediatric rheumatology have played major roles in these advancements that have improved the care of children ...
Ekemini A. Ogbu, Linda T. Hiraki, Mara L. Becker   +2 more
wiley   +1 more source