Results 51 to 60 of about 628,696 (290)

Creep rupture of materials: insights from a fiber bundle model with relaxation

, 2010
I adapted a model recently introduced in the context of seismic phenomena, to study creep rupture of materials. It consists of linear elastic fibers that interact in an equal load sharing scheme, complemented with a local viscoelastic relaxation ...
E. A. Jagla, H. Kawamura, K. Yamaguchi
core   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

A Generalized Accelerated Failure Time Model to Predict Restoration Time from Power Outages

International Journal of Disaster Risk Science
Major disasters such as wildfire, tornado, hurricane, tropical storm, and flooding cause disruptions in infrastructure systems such as power and water supply, wastewater management, telecommunication, and transportation facilities.
Tasnuba Binte Jamal, Samiul Hasan
doaj   +1 more source

Alkaline Water and Longevity: A Murine Study [PDF]

, 2016
The biological effect of alkaline water consumption is object of controversy. The present paper presents a 3-year survival study on a population of 150 mice, and the data were analyzed with accelerated failure time (AFT) model.
Baratella, Davide, Bonaiuto, Emanuela, Corain, Livio, Corraducci, Vittorino, Ferro, Silvia, Magro, Massimiliano, Salmaso, Luigi, Terzo, Milo, Vianello, Fabio   +8 more
core   +3 more sources

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Molecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking   +43 more
wiley   +1 more source

Model Averaging for Accelerated Failure Time Models with Missing Censoring Indicators

Mathematics
Model averaging has become a crucial statistical methodology, especially in situations where numerous models vie to elucidate a phenomenon. Over the past two decades, there has been substantial advancement in the theory of model averaging. However, a gap
Longbiao Liao, Jinghao Liu
doaj   +1 more source

A new engineering approach to predict the long-term hydrostatic strength of unplasticized poly(vinyl chloride) pipes [PDF]

, 2008
Extruded polymer pipes are qualified using pressurized pipe tests. With these tests the long-term hydrostatic strength is determined by subjecting the pipes to an internal pressure, while measuring the time-to-failure.
Bor, T.C., Engels, T.A.P., Govaert, L.E., Patrick, S., Visser, H.A., Wolters, M.   +5 more
core   +1 more source

Semi-quantitative temperature accelerated life test (ALT) for the reliability qualification of concentrator solar cells and cell on carriers [PDF]

, 2015
An adequate qualification of concentrator photovoltaic solar cells and cell-on-carriers is essential to increase their industrial development. The lack of qualification tests for measuring their reliability together with the fact that conventional ...
Bosco, Bosco, Crowe, Espinet, Espinet-González, Fthenakis, Fukuda, Garcia, Gold, González, Green, Hayes, Kececioglu, McConnell, Nelson, Núñez, Suhir, Vázquez   +17 more
core   +2 more sources

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Dietary nitrate and nitrite protect against doxorubicin‐induced cardiac fibrosis and oxidative protein damage in tumor‐bearing mice

FEBS Open Bio, EarlyView.
Chemotherapies such as doxorubicin can have toxic effects on healthy cardiovascular/heart tissue. Following up on a doxorubicin toxicity study in mice without tumors where nitrate water was cardioprotective (lessened toxicity), this study with tumor‐bearing mice undergoing doxorubicin treatment showed no negative effect of nitrate and nitrite on drug ...
Rama D. Yammani, Xiaofei Chen, Nildris Cruz‐Diaz, Xuewei Zhu, Swati Basu, Daniel B. Kim‐Shapiro, David R. Soto‐Pantoja, Leslie B. Poole   +7 more
wiley   +1 more source