Results 61 to 70 of about 125,355 (253)
FEBS Open Bio, EarlyView.This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill +4 more
wiley +1 more source
Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system
FEBS Open Bio, EarlyView.An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková +3 more
wiley +1 more source
The estimation of accelerated failure time model when there are replicate measurements of covariates
, 2013 碩士加速壽命模型(AFT model , accelerated failure time model)具有相當直覺性的解釋，因此它是除了 Cox 比例風險模型外另一個常用的統計模型。但當自變數受測量誤差影響時，目前還未能提出具一致性的估計方法。本文考慮在自變數有重複測量的情形下，修正Tsiatis(1990)提出的估計方法以期能找出在自變數受測量誤差影響能具一致性的估計方法。而我們提出的估計方法具一致性的推測不僅可從理論來證明也可從電腦模擬結果中得到驗證。Accelerated failure ...
陳立誼; Chen, Li-Yi
core
FEBS Open Bio, EarlyView.Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani +6 more
wiley +1 more source
Journal of Statistical Theory and Applications (JSTA), 2018 The step-stress accelerated degradation test (SSADT) is one of the most commonly used time-dependent types of stress loading tests that enables a shorter test duration. This test is more economical and flexible compared to accelerated degradation test or
Somayeh Mireh +2 more
doaj +1 more source
Weighted accelerated failure time model
The accelerated failure time (AFT) model is widely used in survival analysis and auxiliary information can be used to improve the efficiency of the model.
Nayaka Bandaralage, Ayesha Madhushani Rathnayake
core +1 more source
Reliability Analysis Test-Based Interval Estimation Under the Accelerated Failure Time Model [PDF]
, 2007 The accelerated failure time (AFT) model is an important regression tool ...
Yichuan Zhao, Yijian Huang
core
FEBS Open Bio, EarlyView.Abruptly changing from aerobic to anaerobic conditions (sudden anaerobization) induced growth inhibition and a significant increase in intracellular labile ferrous iron in the aerotolerant anaerobe Amphibacillus xylanus. We found that free flavins mediate efficient electron transfer from NADH to ferric iron under anaerobic conditions, suggesting that ...
Shinya Kimata +13 more
wiley +1 more source
A homoscedasticity test for the accelerated failure time model
, 2018 The semiparametric accelerated failure time (AFT) model is a popular linear model in survival analysis. AFT model and its associated inference methods assume homoscedasticity of the survival data.
Liu, L. +5 more
core +1 more source
Versatile vector tools for efficient protein screening across multiple expression systems
FEBS Open Bio, EarlyView.A unified vector toolkit enables rapid protein expression screening across E. coli, insect, and mammalian cells. A single primer pair amplifies the target gene, which is inserted into any vector via a standardized interface. This streamlined workflow eliminates repeated cloning steps, accelerating the identification of optimal expression conditions for
Zhimin Zhu +5 more
wiley +1 more source