Results 41 to 50 of about 125,355 (253)
Results of multivariate accelerated failure time (AFT) model (n = 106,206).
, 2017 Results of multivariate accelerated failure time (AFT) model (n = 106,206).
Petrus Tang (8798) +6 more
core +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
A Generalized Accelerated Failure Time Model to Predict Restoration Time from Power Outages
International Journal of Disaster Risk ScienceMajor disasters such as wildfire, tornado, hurricane, tropical storm, and flooding cause disruptions in infrastructure systems such as power and water supply, wastewater management, telecommunication, and transportation facilities.
Tasnuba Binte Jamal, Samiul Hasan
doaj +1 more source
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
Perbandingan Model Accelerated Failure Time (AFT) dan model cox proportional hazard pada kasus kardiovaskular RSKIA Harapan Bunda Bandung [PDF]
, 2021 Jantung koroner menjadi dominan penyakit yang mematikan di dunia seperti halnya penyakit kardiovaskular. Umumnya, penyakit kardiovaskular menyerang bagian jantung khususnya pembuluh darah.
Qirom, Zuyyina Alfiany Fawzi
core
The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source
BarekengRecidivists, or ex-prisoners who commit crimes after serving a prior sentence, pose a critical challenge to the criminal justice system. This study examines social and economic factors that may reduce the likelihood of recidivists being re-arrested ...
Nuraziza Arfan +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano +6 more
wiley +1 more source
BMC CancerIn this article, we read with great attention the correspondence by Bullement et al., regarding our published study on cost-effectiveness of first-line immunotherapy combinations with or without chemotherapy for advanced non-small cell lung cancer.
Wen Hui +4 more
doaj +1 more source