Results 61 to 70 of about 36,992 (256)

Renal function and morphology in aged Beagle dogs before and after hydrocortisone administration [PDF]

, 2012
Objectives of this study were to evaluate glomerular filtration rate (GFR), renal structural changes and proteinuria in aged Beagle dogs before and after hydrocortisone (HC) administration.
Smets, Pascale, Lefebvre, Hervé P, Aresu, Luca, Croubels, Siska, Haers, Hendrik, Piron, Koen, Meyer, Evelyne, Daminet, Sylvie   +7 more
core   +2 more sources

Extracellular Vesicles of Streptococcus anginosus Mediate Gastritis via Epithelial Barrier Disruption and Macrophage‐driven Inflammation

Advanced Science, EarlyView.
Streptococcus anginosus extracellular vesicles (SA‐EVs) accumulate in gastric tissue, disrupt epithelial tight junctions, and induce gastritis characterized by neutrophil infiltration and elevated cytokines (TNF‐α, IL‐6, IL‐17A). Proteomics identifies TMPC and FBP62 as key SA‐EVs virulence factors; their genetic deletion attenuates inflammation ...
Ying Gong, Lina Duan, Jie Xiao, Yulu Deng, Hongxia Wang, Yajie Zhang, Xiumei Hu, Haifang Wang, Taixue An, Xin Li, Yurong Qiu, Lei Zheng, Haixia Li   +12 more
wiley   +1 more source

Statistical Inference for the Modified Fréchet-Lomax Exponential Distribution Under Constant-Stress PALT with Progressive First-Failure Censoring

Mathematics
Life testing of products often requires extended observation periods. To shorten the duration of these tests, products can be subjected to more extreme conditions than those encountered in normal use; an approach known as accelerated life testing (ALT ...
Ahmed T. Farhat, Dina A. Ramadan, Hanan Haj Ahmad, Beih S. El-Desouky   +3 more
doaj   +1 more source

Anti‐Apoptotic and Neurite‐Protective Nanomedicine Augments Embryonic Stem Cells‐Derived Retinal Ganglion Cell Transplantation in Glaucoma Recovery

Advanced Science, EarlyView.
Lithium‐epigallocatechin gallate nanoparticles (Li‐EGCG NPs) are co‐transplanted with embryonic stem cell‐derived retinal ganglion cells (ESC‐RGCs) to enhance cell survival and therapeutic efficacy in an acute pathological glaucomatous injury model. This synergistic approach protects RGC cells, preserves retinal structure and improves visual function ...
Moxin Chen, Xiaoyan Jiang, Yuanhui Wang, Zhaobin Luo, Yu Zhang, Siwei Liu, Rui Huang, Dandan Zhang, Zhimin Tang, Yahan Ju, Shaohui Pan, Ni Ni, Wei Feng, Yu Chen, Ping Gu   +14 more
wiley   +1 more source

Engineered GM1 Intersects Between Mitochondrial and Synaptic Pathways to Ameliorate ALS Pathology

Advanced Science, EarlyView.
Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease driven by genetic and molecular disruptions affecting energy balance, protein homeostasis, and stress responses in nerve cells. Studies using human and rodent models identified convergent defects in mitochondria and synaptic function.
Federica Pilotto, Tristan Dellazizzo Toth, Silvano Bond, Alexander Schmitz, Rim Diab, Sara Y. Ngo Tenlep, Brian Mooney, Silvia Erni, Martina Schobesberger, Olivier Scheidegger, Camille Peitsch, Smita Saxena   +11 more
wiley   +1 more source

Intrinsic aerobic capacity sets a divide for aging and longevity [PDF]

, 2011
<p><b>Rationale:</b> Low aerobic exercise capacity is a powerful predictor of premature morbidity and mortality for healthy adults as well as those with cardiovascular disease.
Charles F. Burant, Elizabeth M. van Grevenhof, Godfrey L. Smith, Helene Wisløff, John E. Wilkinson, Lauren Gerard Koch, Lori J. Gilligan, Morten A. Høydal, Natale Rolim, Nathan Qi, Ole J. Kemi, Peter M. Abadir, Piter Bijma, Sean X. Leng, Steven L. Britton, Tosato M, Ulrik Wisløff, Øyvind Ellingsen   +17 more
core   +3 more sources

Ufmylation‐Deficient DDRGK1 Ameliorates Obesity by Inhibiting FASN‐Mediated Adipocyte Lipogenesis

Advanced Science, EarlyView.
DDRGK1 regulates de novo lipogenesis via stabilization of fatty acid synthase (FASN). DDRGK1‐mediated UFMylation of FASN prevents its ubiquitin–proteasomal degradation. Reduced DDRGK1 expression or mutation at the key UFMylation site enhances FASN degradation and suppresses fatty acid synthesis (FAS), resulting in smaller adipocytes and improved ...
Yin Li, Tangjun Zhou, Xiao Yang, Kewei Rong, Xiankun Cao, Lei Shi, Xin Wang, Hongjin Wan, Lei Cui, Kexin Liu, Tong Xing, Hang Zhang, Chen Zhao, Tingxian Guo, Peixiang Ma, Jie Zhao, An Qin   +16 more
wiley   +1 more source

Towards Prognostics of Power MOSFETs: Accelerated Aging and Precursors of Failure [PDF]

, 2010
This paper presents research results dealing with power MOSFETs (metal oxide semiconductor field effect transistor) within the prognostics and health management of electronics.
Celaya, Jose R., Goebel, Kai, Saha, Sankalita, Saxena, Abhinav, Wysocki, Philip   +4 more
core   +1 more source

Summary report for a hydrogen sensor workshop: Hydrogen safety sensors and their use in applications with hydrogen as an alternative fuel [PDF]

, 2017
On May 10, 2017, a Hydrogen Sensor Workshop was held in Brussels, Belgium. The workshop was jointly organised by the sensor test laboratories at the Joint Research Centre (Petten, Netherlands) and the National Renewable Energy Laboratory (Golden ...
BONATO CHRISTIAN, BUTTNER WILLIAM, ORTIZ CEBOLLA RAFAEL, WEIDNER RONNEFELD EVELINE   +3 more
core   +2 more sources

Phase Separation of NFIB Suppresses SLC3A2‐Mediated Ferroptosis in Castration‐Resistant Prostate Cancer

Advanced Science, EarlyView.
Castration‐resistant prostate cancer (CRPC) remains sensitive to ferroptosis, but its intrinsic resistance is poorly understood. Here, we identify NFIB as a master suppressor. SIRT7‐mediated NFIB acetylation drives its liquid–liquid phase separation, which promotes SLC3A2 transcription to inhibit ferroptosis.
Qiunuo Li, Danyang Chen, Yongzhen Xia, Yili Long, Nan Huang, Rongna Li, Mengting Shi, Mairehaba Kadier, Huafeng Luo, Xiaohui Chen, Hao Liu, Guanmin Jiang   +11 more
wiley   +1 more source