Results 91 to 100 of about 5,548,205 (246)

Timescales for detecting a significant acceleration in sea level rise [PDF]

, 2014
There is observational evidence that global sea level is rising and there is concern that the rate of rise will increase, significantly threatening coastal communities.
Pattiaratchi, Charitha B., Calafat, Francisco M., Rohling, Eelco J., Rohling, Eelco, Haigh, Ivan D., Calafat, Francisco, Wahl, Thomas, Dangendorf, Sönke, Price, René M., Pattiaratchi, Charitha   +9 more
core   +1 more source

Torsional Response Induced by Lateral Displacement and Inertial Force

Frontiers in Built Environment, 2018
Eccentric distribution of stiffness, damping, and mass of a structure, and spatially non-uniform ground motion input to a long or large base mat of a structure are well-known causes of torsional response.
Masayuki Kohiyama, Hiroki Yokoyama
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Tactile Cross-Modal Acceleration Effects on Auditory Steady-State Response

Frontiers in Integrative Neuroscience, 2019
In the sensory cortex, cross-modal interaction occurs during the early cortical stages of processing; however, its effect on the speed of neuronal activity remains unclear.
Shunsuke Sugiyama, Tomoaki Kinukawa, Nobuyuki Takeuchi, Makoto Nishihara, Toshiki Shioiri, Koji Inui   +5 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Change-Related Acceleration Effects on Auditory Steady State Response

Frontiers in Systems Neuroscience, 2019
Rapid detection of sensory changes is important for survival. We have previously used change-related cortical responses to study the change detection system and found that the generation of a change-related response was based on sensory memory and ...
Shunsuke Sugiyama, Tomoaki Kinukawa, Nobuyuki Takeuchi, Makoto Nishihara, Toshiki Shioiri, Koji Inui, Koji Inui   +6 more
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

The Shock Characteristics of Tilted Support Spring Packaging System with Critical Components

Shock and Vibration, 2014
The nonlinear dynamical equations of tilted support spring packaging system with critical components were obtained under the action of half-sine pulse. To evaluate the shock characteristics of the critical components, a new concept of three-dimensional ...
An-Jun Chen
doaj   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

NAPRT loss promotes lung tumor initiation and growth through AKT signaling independently of NAD+ biosynthesis

Molecular Oncology, EarlyView.
Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh, Ji Yun Jang, Yoon Jeon, Gi‐Cheon Kim, Hwanho Lee, Jooyoung Lee, Ju‐Hwa Kim, Hakhyun Kim, Minjee Kim, Ho‐Keun Kwon, Ho Lee, Hyun Seok Kim   +11 more
wiley   +1 more source