Results 71 to 80 of about 264,692 (309)
RIPK4 function interferes with melanoma cell adhesion and metastasis
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski +9 more
wiley +1 more source
We report on results from Suzaku broadband X-ray observations of the southwest part of the Galactic supernova remnant (SNR) RX J1713.7-3946 with an energy coverage of 0.4-40 keV.
Bamba, Aya +15 more
core +1 more source
SmallTalk: a novel small‐sized fusion tag for peptide expression and purification
The SmallTalk fusion tag allows for the efficient expression and purification of soluble recombinant proteins or peptides in Escherichia coli. Testing with SmallTalk‐GFP confirmed that the proteins were soluble and folded correctly, while SmallTalk‐Bin1b maintained its antimicrobial activity against various bacterial isolates. This streamlined workflow
Atika Tariq +3 more
wiley +1 more source
Analyses of strong motion earthquake accelerograms, Volume III - Response spectra; Part F - Accelerograms IIF086 through IIF105 [PDF]
This is the sixth report of a series presenting earthquake response spectrum curves calculated from corrected ground accelerograms. In the Preface to the first part, Volume III, Part A, Report No.
Earthquake Engineering Research Laboratory,
core
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei +3 more
wiley +1 more source
Determination of design spectrum compatible evolutionary spectra via Monte Carlo peak factor estimation [PDF]
The problem of generating ensembles of artificial non-stationary earthquake accelerograms compatible with a given (target) response/design spectrum is cast on a stochastic basis.
Giaralis, A., Spanos, P. D.
core
The Aging Blood: Cellular Origins, Circulating Drivers, and Therapeutic Potential
As a conduit linking all organs, the blood system both reflects and actively drives systemic aging. This review highlights how circulating pro‐aging and antiaging factors and age‐associated hematopoietic stem cell dysfunction contribute to immunosenescence and multi‐organ decline, positioning the hematopoietic system as a target for aging intervention.
Hanqing He, Jianwei Wang
wiley +1 more source
鉴于传统的地震动强度表征参数(IM)不能有效地反映速度脉冲型地震动的破坏特征,需要研究能够在全周期段内表征速度脉冲型地震动强度的参数。本文首先从NGA-West2强震数据库中选取了236条速度脉冲记录,分析了42种地震动参数之间的相似性和相关性,初步给出了速度脉冲型地震动强度的表征参数;其次,利用单自由度体系动力时程分析方法,研究了不同延性μ条件下速度脉冲型地震动强度表征参数与最大非线性位移um之间的相关性系数随周期T的变化特征 ...
Xiaofen Zhao +3 more
doaj +1 more source
A ride quality meter is disclosed that automatically transforms vibration and noise measurements into a single number index of passenger discomfort. The noise measurements are converted into a noise discomfort value.
Clevenson, S. A. +3 more
core +1 more source
A Novel Approach in Constraining Electron Spectra in Blazar Jets: The Case of Markarian 421
We report results from the observations of the well studied TeV blazar Mrk 421 with the Swift and the Suzaku satellites in December 2008. During the observation, Mrk 421 was found in a relatively low activity state, with the corresponding 2-10 keV flux ...
Hayashida, M. +9 more
core +1 more source

