Results 51 to 60 of about 265,284 (302)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Research on the Influence of the Target Spectrum and Amplitude Scaling Method on the Dynamic Time History Analysis Results of a High-Rise Building Structure

Buildings
This study addresses the critical need for region-specific ground motion selection methods in the Xi’an area by proposing a novel Peak Ground Acceleration (PGA)-based target spectrum, developed through the relationship between PGA and response spectrum ...
Jianhui Niu, Yupeng Xie, Penggang Tian, Kai Wang, Zhiheng Tian, Ergang Xiong, Feng Yue   +6 more
doaj   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Ground motion of the Ms7.0 Jiuzhaigou earthquake

Open Geosciences, 2021
Eighty-eight free-field strong ground motion observation datasets obtained by the National Strong Motion Observation Network System of China for the Jiuzhaigou Ms7.0 earthquake were used to study the characteristics of the strong ground motion and the ...
Wang Wencai, Chen Jifeng, Su Xiaoyun, Wu Lina, Chen Lijun, Jiang Zhijie, Shi Wenbing, Wang Yan, Liu Hongmei   +8 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Analyses of strong motion earthquake accelerograms, Volume III - Response spectra; Part A - Accelerograms IIA001 through IIA020 [PDF]

, 1972
This is the first volume of a series presenting earthquake response spectrum curves calculated from corrected ground accelerograms. An introduction summarizes response spectrum techniques in earthquake engineering as a background to the use of the data ...
Earthquake Engineering Research Laboratory,
core  

Research on Improved Seismic Instrumentation System for Nuclear Power Plants

Energies, 2021
According to the requirements of nuclear safety regulations, nuclear power plants must be equipped with seismic instrumentation systems, which are mainly used for monitoring alarm and automatic shutdown alarm during an earthquake.
Liang Li, Xiuli Du, Rong Pan, Xiuyun Zhu, Haiyan Luan   +4 more
doaj   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Acceleration Signal Processing Method of Impact Response of Floating Shock Platform Based on Rigid Body Motion Model

Shock and Vibration, 2020
Floating shock platform is generally used to test the antishock performance of large shipboard equipment. Shock acceleration signal will produce zero-shift phenomenon in the test measurement process, which will affect the subsequent shock response ...
Xiongliang Yao, Wenqi Zhang, Zhikai Wang, Jin Chen, Heng Yang   +4 more
doaj   +1 more source