Results 71 to 80 of about 44,282 (251)

Innate Immune Reprogramming Mediated by Endogenous Retroelement Dysregulation Drives Multiple Sclerosis Progression

Annals of Clinical and Translational Neurology, EarlyView.
Epigenetic reprogramming in hematopoietic stem and progenitor cells (HSPCs) and downstream myeloid cells, mediated by H3.3 downregulation and endogenous retroelement (ERE) overexpression, contributes to the progression of multiple sclerosis (MS). ABSTRACT Background Skewed myelopoiesis in the bone marrow has been identified as a key driver of multiple ...
Li‐Mei Xiao, Qiu‐Ping Zhao, Run‐Yun Li, Wei Chen, Huan‐Huan Song, Wan‐Jin Chen, Ying Fu   +6 more
wiley   +1 more source

A Comparative Study on the Design Spectra Defined by Several Codes of Practice on RC Building Located in Baghdad City

مجلة النهرين للعلوم الهندسية, 2017
This paper studies the effect of different design spectral response acceleration parameters as suggested by the uniform building code (UBC), unified facilities criteria (UFC), and Iraqi seismic code(1997) (ISC 97) on the seismic response of reinforced ...
Husain Khalaf Jarallah, Zahir Noori M. Taki   +1 more
doaj  

Safety assessment of the seismic resistance of nuclear power plant technology

MATEC Web of Conferences, 2017
This paper gives the methodology to get the floor response spectra of the buildings on the base of the results of the probabilistic assessment. On the base of the geophysical and seismological monitoring of locality the peak ground acceleration and the ...
Králik Juraj
doaj   +1 more source

An Improved Adaptive Genetic Algorithm for Optimizing Pyroshock Acceleration Synthesis

IEEE Access, 2019
The shock response spectrum (SRS) applied to pyroshock designs and tests for space systems does not include input acceleration time history; therefore, it cannot be used directly in structural nonlinear dynamic analysis before acceleration time history ...
Wenjuan Sun, Yingqing Huang, Haibo Chen
doaj   +1 more source

Elevated Connectivity During Language Processing Is Associated With Cognitive Performance in SeLECTS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Self‐Limited Epilepsy with Centrotemporal Spikes (SeLECTS) is associated with language impairments despite seizures originating in the motor cortex, suggesting aberrant cross‐network interactions. Here we tested whether functional connectivity in SeLECTS during language tasks predicts language performance.
Wendy Qi, Katharine Lee, Kerry C. Nix, Miguel Menchaca, Xiwei Shé, Lorelei Santa Maria, Wei Wu, Zihuai He, Fiona M. Baumer   +8 more
wiley   +1 more source

适用于全周期结构的速度脉冲型地震动强度表征参数研究

Dizhen xuebao, 2019
鉴于传统的地震动强度表征参数（IM）不能有效地反映速度脉冲型地震动的破坏特征，需要研究能够在全周期段内表征速度脉冲型地震动强度的参数。本文首先从NGA-West2强震数据库中选取了236条速度脉冲记录，分析了42种地震动参数之间的相似性和相关性，初步给出了速度脉冲型地震动强度的表征参数；其次，利用单自由度体系动力时程分析方法，研究了不同延性μ条件下速度脉冲型地震动强度表征参数与最大非线性位移um之间的相关性系数随周期T的变化特征 ...
Xiaofen Zhao, Zengping Wen, Bo Chen, Yijun Liu   +3 more
doaj   +1 more source

Movement Disorders in Aicardi–Goutières Syndrome and Response to Immunomodulation

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT This study characterizes movement disorders and treatment responses in seven children with Aicardi–Goutières syndrome (AGS). We retrospectively evaluated motor phenotypes, neuroimaging, and interferon signatures in patients treated with baricitinib or anifrolumab. Spasticity affected all patients, while dystonia was present in 4/7.
Enrique Gonzalez Saez‐Diez, Monica Ferrer Socorro, Kathryn Yang, Nicole Battaglia, Zainab Zaman, Mariko Bennett, Adeline Vanderver, Pui Y. Lee, Lauren A. Henderson, Milena M. Andzelm, Darius Ebrahimi‐Fakhari   +10 more
wiley   +1 more source

Dynamic characteristics of unsaturated loess and their influences on ground vibration parameters of sites

Yantu gongcheng xuebao, 2019
The dynamic triaxial tests on the unsaturated loess in Xiji region of Ningxia under different water contents are carried out. Based on the analysis of the influences of water content on the dynamic characteristics of loess, the influences of water ...
WEI Lai 1, LU Yu-xia 1,2,3, ZHOU Zheng-hua 4, WANG Qian 1, 2, 3, YANG Bo 1, TANG Hong-min 1, LI Tong-lin 1
doaj   +1 more source

MOGAD Is the Most Common Cause of Isolated Optic Neuritis in Children

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives The study aimed to characterize the clinical features, etiologies, and outcomes of isolated, first‐time pediatric ON in the post‐MOG‐IgG era. Methods This was a single‐center retrospective cohort study at Texas Children's Hospital of patients diagnosed with first‐time ON between 2018–2024, with follow‐up data collected through 2025.
Chaitanya Aduru, Akansha Chandrasekar, Kyla Blasingame, Jonathan Rosen, Jesse M. Levine, Karla Salazar, Madhuri Chilakapati, Rod Foroozan, Victoria Hardwick, Jonathan M. Yarimi, Nikita Shukla, Timothy E. Lotze, Kristen S. Fisher, Alexander J. Sandweiss   +13 more
wiley   +1 more source

Artificial Intelligence in Systemic Sclerosis: Clinical Applications, Challenges, and Future Directions

Arthritis Care &Research, EarlyView.
Systemic sclerosis (SSc) is a rare autoimmune disease defined by immune dysregulation, vasculopathy, and progressive fibrosis of the skin and internal organs. Despite advances in care, major complications such as interstitial lung disease (ILD) and myocardial involvement remain the leading causes of morbidity and mortality.
Cristiana Sieiro Santos, José Miguel Sequí‐Sabater, Diego Benavent   +2 more
wiley   +1 more source