Results 101 to 110 of about 50,001 (309)

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

open access: yesFEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara   +3 more
wiley   +1 more source

ACCDIST: A Metric for comparing speakers' accents

open access: yes, 2004
This paper introduces a new metric for the quantitative assessment of the similarity of speakers' accents. The ACCDIST metric is based on the correlation of inter-segment distance tables across speakers or groups.
Huckvale, M
core  

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

open access: yesFEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee   +7 more
wiley   +1 more source

Phonological Analysis of University Students’ Spoken Discourse

open access: yesHumaniora, 2011
The study of discourse is the study of using language in actual use. In this article, the writer is trying to investigate the phonological features, either segmental or supra-segmental, in the spoken discourse of Indonesian university students. The data
Clara Herlina
doaj  

Hierarchical clustering of speakers into accents with the ACCDIST metric

open access: yes, 2007
Hierarchical clustering of speakers by their pronunciation patterns could be a useful technique for the discovery of accents and the relationships between accents and sociological variables.
Huckvale, M
core  

Accent recognition: a perceptual-dialectological study of Frisian

open access: yes
Map-based accent recognition experiment using QualtricsMap-based accent recognition experiment using ...
Research Software Lab, Centre for Digital Humanities, Utrecht University
core   +1 more source

The ACCENT Policy Wizard [PDF]

open access: yes, 2009
The ACCENT project (Advanced Component Control Enhancing Network Technologies) developed a practical and comprehensive policy system for call control/Internet telephony.
Turner, Kenneth J, Campbell, Gavin A
core  

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

open access: yesFEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

L’anacrouse comme modèle pour appréhender le travail phonétique en langue française [PDF]

open access: yesSynergies Espagne, 2017
Cet article explore le parallèle que l’on peut établir entre musique et parole dans le cas de la langue française, en particulier dans le domaine du rythme. À partir de l’état des lieux qu’il dresse sur la question, il se propose de montrer que l’on peut
Cécilia Debergh
doaj  

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

open access: yesFEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

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