Results 61 to 70 of about 228,055 (288)

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Interventions for adjustment, impaired self-awareness and empathy [PDF]

, 2017
No abstract ...
Ashworth, Fiona, McLeod, Hamish, McMillan, Tom M.   +2 more
core   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

ACT: An overview of acceptance and commitment therapy [PDF]

, 2012
Acceptance and Commitment Therapy (ACT) is an innovative approach to psychotherapy. Currently, the American Psychological Association lists it as an empirically supported treatment for depression.
Richards, Danielle
core  

Mindfulness: A foothold for Rogers's humanistic person-centred approach [PDF]

, 2015
This article probed and contextualised the strong parallels between meditation derived mindfulness and Rogers's humanistic person-centred (PC) approach.
Edwards, David J., Jooste, Julius, Kruger, Ankebé, Steyn, Barend J. M.   +3 more
core   +3 more sources

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Acceptance and commitment therapy for adults with advanced cancer (CanACT): study protocol for a feasibility randomised controlled trial [PDF]

, 2016
BACKGROUND: One-third of people with cancer experience psychological distress and may suppress distressing thoughts, emotions, and concerns, leading to further problems.
Austen, JS, Davis, S, Gola, A, Jones, L, King, M, Low, J, Omar, RZ, Serfaty, M, Tookman, A, Turner, K, Vickerstaff, V   +10 more
core  

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

A comparison of cognitive restructuring and thought listing for excessive acquiring in hoarding disorder [PDF]

, 2019
Excessive acquiring is a common symptom of hoarding disorder (HD). Little is known about subjective distress associated with acquiring in HD. The present study examined acquiring- related distress and reactions to cognitive restructuring (CR) in 92 ...
Frost, Randy O., Levy, Hannah C., Offermann, Elizabeth A., Steketee, Gail, Tolin, David F.   +4 more
core   +2 more sources

The effects of a mindfulness-based program on the incidence of injuries in young male soccer players [PDF]

, 2020
We tested the effectiveness of a mindfulness-based program in reducing sport injury incidence. 168 young male elite soccer players were randomly assigned to mindfulness (MG) and control (CG) groups. The MG consisted of 7 sessions based on the Mindfulness-
Andrews, Barkley, Bates, Bergomi, Brewer, Brown, Caglar, Carmody, De Petrillo, Drew, Edvardsson, Ekstrand, Folkman, Fox, Fuller, Gardner, Garland, Garland, Glass, Goldin, Hayes, Hayes, Hägglund, Hägglund, Hölzel, Hölzel, Ivarsson, Ivarsson, Ivarsson, Jain, Johnson, Kessler, Kiken, Lau, MacKinnon, Noetel, Ortner, Perna, Pfirrmann, Plemmons, Powell, Putukian, Rogers, Scott-Hamilton, Segal, Shapiro, Smith, Stubbe, Thienot, Tranaeus, Weinstein, Williams   +51 more
core   +2 more sources