Results 61 to 70 of about 45,427 (265)

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Effectiveness of Acceptance and Commitment Therapy on the Marital Satisfaction and Sexual Performance in Couples with Emotional Divorce [PDF]

Iranian Journal of Educational Research, 2023
Objective: The purpose of this study was to examine the impact of acceptance and commitment therapy on marital satisfaction and sexual performance in couples experiencing emotional divorce.
Mohammad Hossein Zebhi Zarchi, Fatemeh Jalayer, Tayebeh Gholamzadeh Bafghi, Elnaz Hajiyousefi, Behnaz Hatamikia, Fattaneh Amirmahmoudi   +5 more
doaj  

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Comparison of the effectiveness of cognitive–behavioral therapy and acceptance and commitment therapy on depression symptoms and hypersexual behaviours in patients with sex addiction

مجله علوم روانشناختی, 2021
Background: Numerous studies have addressed the impact of cognitive-behavioral therapy and treatment based on acceptance and commitment to depression. However, there is a research gap between comparing the effectiveness of cognitive-behavioral therapy ...
Reihaneh Firoozikhojastehfar, Karim Asgari, Mehrdad Kalantari, Firoozeh Raisi, Zahra shahvari   +4 more
doaj  

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Comparing The Effectiveness Of Dialectical Behavior Therapy And Acceptance And Commitment Therapy On Distress Tolerance In Adolescent Boys With Internet Addiction [PDF]

Taḥqīqāt-i ̒Ulūm-i Raftārī
Aim and Background: This study aimed to compare the effectiveness of dialectical behavior therapy and acceptance and commitment therapy on distress tolerance in adolescent boys with Internet addiction.
piran kamalzade, khalil esmaeilpour, touraj hashemi   +2 more
doaj  

Attitudes of cancer patients toward ctDNA‐based liquid biopsy for follow‐up

Molecular Oncology, EarlyView.
This mixed‐methods study explored cancer patients' experiences, knowledge, and preferences regarding ctDNA‐based liquid biopsy for follow‐up. Awareness of ctDNA was low and recall of previous liquid biopsy was imperfect, yet acceptance was high.
Siddharth Chhajlani, Laura Mariën, Caro De Weerdt, Sanne Wouters, Laure‐Anne Teuwen, Hans Prenen, Katleen Janssens, Timon Vandamme   +7 more
wiley   +1 more source

Comparison of the Effectiveness of Acceptance and Commitment Therapy, Mindfulness, and Motivational Interviewing on Intentional Self-Regulation in Individuals with Substance Use Disorder under Maintenance Therapy [PDF]

Research on Addiction, 2023
Objective: The present research aimed to compare the effectiveness of acceptance and commitment therapy, mindfulness, and motivational interviewing on intentional self-regulation in individuals with substance use disorder under maintenance therapy ...
mahsa Kashefizadeh, mahboobe Taher, Abbas Ali Hosseinkhanzadeh, narges Haj Abootalebi   +3 more
doaj