Results 41 to 50 of about 170,171 (257)

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

New psychological therapies for irritable bowel syndrome: mindfulness, acceptance and commitment therapy (ACT)

Revista Española de Enfermedades Digestivas, 2017
The current goal of treatment in irritable bowel syndrome (IBS) focuses primarily on symptom management and attempts to improve quality of life. Several treatments are at the disposal of physicians; lifestyle and dietary management, pharmacological treatments and psychological interventions are the most used and recommended.
Sebasián Sánchez, Beatriz, GIl Roales-Nieto, Jesús, Ferreira, Nuno B., Gil Luciano, Bárbara, Sebastián Domingo, Juan José   +4 more
openaire   +7 more sources

Acceptance and Commitment Therapy pada Pasien Skizofrenia dengan Halusinasi [PDF]

, 2023
This study aims to determine the effectiveness of acceptance and commitment therapy in schizophrenic patients with hallucinations. The method used in this study is a systematic literature review with a structured and systematic search on Embase, Clinical
Daulima, Novy Helena Catharina, Mustikasari, Mustikasari, Yoduke, Fandy   +2 more
core   +2 more sources

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Acceptance and Commitment Therapy (ACT) aplication toward self acceptance and commitment to prevent the transmission of HIV/AIDS

LINK, 2015
For people living with HIV/AIDS (PLWHA), to be diagnozed AIDS is a big problem. Psychologic problem of PLWHA will lead negative behaviour toward himself such as tend to suicide since the transmission of HIV/AIDS will be cut off if it is done.
Widjijati Widjijati, Dyah Wahyuningsih, Aris Fitriyani   +2 more
doaj   +1 more source

Efecto de una guía de intervención clínica basada en la Terapia de Aceptación y Compromiso, sobre la flexibilidad psicológica en excombatientes colombianos [PDF]

, 2019
Trabajo de investigaciónEl objetivo de esta investigación fue determinar el efecto de la guía de intervención clínica basada en la Terapia de Aceptación y Compromiso ACT) en el aumento de los procesos de aceptación experiencial, defusión cognitiva ...
Baer, Barnard, Bishop, Brown, Cardaciotto, Davies, Fennell, García-Campayo, Germer, Germer, Gilbert, Gilbert, Gilbert, Goetz, Grossman, Grossman, Gunaratana, Hayes, Jopling, Kabat-Zinn, Kabat-Zinn, Keng, Lama, Lama, Lama, Langer, Lazarus, Mayhew, Neff, Neff, Neff, Neff, Neff, Osho, Perez-Bret, Pos, Sauer, Siegel, Simón, Simón, Sprecher, Teasdale, Thera, Thich Nhat Hanh, Torralba Roselló, Vallejo, Virgili, Vreeland, Watts, Wispé   +49 more
core   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Effects of acceptance and commitment therapy on cognitive function: A systematic review

Heliyon, 2023
Cognitive function is essential for daily activities. Acceptance and commitment therapy (ACT) may improve cognitive function by enhancing psychological flexibility, but the underlying mechanism is unknown.
Haihong Liu, Nan Liu, Sheau Tsuey Chong, Eugene Koh Boon Yau, Abdul Rahman Ahmad Badayai   +4 more
doaj   +1 more source

Novel approaches in treatment of pediatric anxiety [PDF]

, 2014
Pediatric anxiety disorders have high prevalence rates and morbidity and are associated with considerable functional impairment and distress. They may be predictors for the development of other psychiatric disorders and, without intervention, are more ...
Geller, Daniel A., Park, Jennifer M.
core   +1 more source