Results 41 to 50 of about 20,221 (298)

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Exploring Values with Adolescents: Implications of Acceptance and Commitment Therapy

Psikiyatride Güncel Yaklaşımlar
Adolescents need both developmental support and a set of compass and value-based competencies to effectively navigate and make sense of the present events and situations they meet, ultimately leading to a purposeful and fulfilling life.
Merve Demir, Ömer Faruk Kabakçı
doaj   +1 more source

Acceptance and Commitment Therapy (ACT) aplication toward self acceptance and commitment to prevent the transmission of HIV/AIDS

LINK, 2015
For people living with HIV/AIDS (PLWHA), to be diagnozed AIDS is a big problem. Psychologic problem of PLWHA will lead negative behaviour toward himself such as tend to suicide since the transmission of HIV/AIDS will be cut off if it is done.
Widjijati Widjijati, Dyah Wahyuningsih, Aris Fitriyani   +2 more
doaj   +1 more source

Acceptance and Commitment Therapy in Group Format for College Students [PDF]

We randomly assigned 71 student participants to an acceptance and commitment therapy (ACT) group training or to a wait list. All participants completed measures at preintervention, 1-month postintervention, and 2-month follow-up.
Lloyd, Jo, Flaxman, P. E., Christodoulou, V.   +2 more
core   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Acceptance and commitment therapy: An existential approach to therapy? [PDF]

, 2015
This paper aims to explore the similarities and tensions between Acceptance and Commitment Therapy (ACT) and existential-phenomenological therapy. Parallel processes and attitudes are outlined, and conceptual and historical differences are discussed. The
Ramsey-Wade, Christine
core  

The Development of the Acceptance and Commitment Therapy Fidelity Measure (ACT-FM): A Delphi Study and Field Test. [PDF]

, 2019
Being able to assess whether psychological therapies are delivered according to their own principles is helpful for assuring treatment quality in research and training.
Latchford, G, Graham, Christopher D.,, McCracken, Lance M.; id_orcid, latchford, Gary, McCracken, Lance, O'Neill, L, McCracken, LM, Latchford, Gary,, O'Neill, Lucy,, McCracken, Lance M., O'Neill, Lucy, Graham, Christopher D., McCracken, Lance M.,, Graham, CD   +13 more
core   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source