Results 51 to 60 of about 184,552 (305)

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Effects of acceptance and commitment therapy on cognitive function: A systematic review

Heliyon, 2023
Cognitive function is essential for daily activities. Acceptance and commitment therapy (ACT) may improve cognitive function by enhancing psychological flexibility, but the underlying mechanism is unknown.
Haihong Liu, Nan Liu, Sheau Tsuey Chong, Eugene Koh Boon Yau, Abdul Rahman Ahmad Badayai   +4 more
doaj   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

The effectiveness of acceptance- and commitment-based therapy on perception of disease in patients with irritable bowel syndrome

International Archives of Health Sciences, 2020
Aims: The purpose of this study was to investigate the effectiveness of acceptance and commitment therapy on perception of disease in patients with irritable bowel syndrome (IBS).
Sedighe Aghalar, Fardin Moradi Manesh, Naser Saraj Khorami, Fariba Hafezi   +3 more
doaj   +1 more source

Kritik Diri dan Kelenturan Psikologis pada Mahasiswa Indonesia : Implikasi Terhadap Intervensi Acceptance and Commitment Therapy (ACT)

Jurnal Paedagogy, 2023
his study aims to examine the relationship between self-criticism and psychological inflexibility as a basis for ACT interventions in college students. The research method used correlation with a quantitative approach.
Diana Syamila, Eka Wahyuni
doaj   +1 more source

An exploratory study into the association between Acceptance and Commitment Therapy (ACT) coping styles, Posttraumatic Stress, and Posttraumatic Growth in working age adults who have experienced a traumatic life event [PDF]

, 2013
Although recent research and theory indicates that posttraumatic stress disorder (PTSD) treatment might benefit from the utilisation of coping styles facilitated by Acceptance and Commitment Therapy (ACT), there has been little research exploring the ...
West, Jade
core  

Symptom experiences in metastatic breast cancer patients: relationships to activity engagement, value-based living, and psychological inflexibility [PDF]

, 2016
OBJECTIVE: This study examined symptom-based subgroups of metastatic breast cancer (MBC) patients and the extent to which they differed across key constructs of acceptance and commitment therapy (ACT). METHODS: Eighty women with MBC completed self-
Bricker, Jonathan, Hirsh, Adam, Johns, Shelley A., Matthias, Marianne S., Miller, Kathy, Mina, Lida, Mosher, Catherine E., Newton, Erin, Outcalt, Samantha D., Rand, Kevin L., Schneider, Bryan, Storniolo, Anna Maria, Tometich, Danielle B.   +12 more
core   +1 more source

Diabetes‐induced vascular calcification is associated with low pyrophosphate and its oral supplementation prevents calcification in diabetic mice

FEBS Open Bio, EarlyView.
Induction of diabetes in three different mouse strains uniformly resulted in an increase in TNAP activity and a reduction in pyrophosphate (PPi) in the circulation. Inhibition of TNAP restored plasma PPi. Diabetes‐induced calcification in the media layer of the aorta was detected only in the Abcc6−/− strain, which is predisposed to ectopic ...
Krisztina Fülöp, Eszter Kozák, Natália Tőkési, Lilian Kocsis, Anikó Kelemen, Zsuzsanna Geszti, Adriána Kutás, Mariann Harangi, Ágnes Diószegi, Zsolt Rapi, József Balla, Olivier Le Saux, András Váradi, Viola Pomozi   +13 more
wiley   +1 more source

The comparison of the effectiveness of acceptance and commitment therapy (ACT) and imagotherapy on the resilience of married women referring to consulting centers in the city of Tehran

مجله علوم روانشناختی, 2019
Background: Marital conflicts reduce couples’ resilience. But can acceptance and commitment therapy and imagotherapy help improve the resilience of married women referring to consulting centers?
samane nikkhah, masome behboodi, parivash vakili   +2 more
doaj