FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source
Concerning Accessibility [PDF]
Proceedings of the National Academy of Sciences, 1939 openaire +2 more sources
Figure A-1, Dakota Access Pipeline Project, Dakota Access, LLC, project overview
Path: R:\ETC\80879_DAPL\GIS\DataFiles\ArcDocs\BA_Maps\BA_Fall2015\A01_Pg1_BA_Overview_AIIActionAreas.mxd jdringman 11/4/2015 COPYRIGHT© 2015 BURNS & McDONNELL ENGINEERING COMPANY, INC.
Dakota Access, LLC;
core +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Dakota Access Pipeline Project, Dakota Access, LLC, PCN map, North Dakota, PCN review area 2
IT ■ f. i iS'l Feature ID: p-d-mt-002 Wetland Type: PUB Crossing Type: >500’ Grossing Lat: 48.29, Long: -102.48 Impacts: 0.905706 :.'s. Feature ID: w-k2-mt-018 Wetland Type: REM Grossing Type: >500’ Crossing Lat: 48.29, Long: -102.47 Impacts: 4.68245 ...
Dakota Access, LLC;
core +1 more source
Is the pharmaceutical industry improving with regard to access to essential medicines?
The Lancet Global Health, 2014 Hans V Hogerzeil +4 more
doaj +1 more source
Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding
FEBS Letters, EarlyView.In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança +2 more
wiley +1 more source
Dakota Access Pipeline Project, Dakota Access, LLC, PCN map index, Illinois - St. Louis District
Path: R:\Projects\14\146\114027000_EnergyTransfer_DAPL_Confidential\GIS\MXD\Permit_Figures\DAPL_Permit_Figures_lndex_St_Louis_20141222.mxd Melisa.Bernard 12/22/2014 --I ^ r I XffjnTvfcf'^ ,1>'| Review Area 1 PCN Review Area 2 Lat: 39.89|^^ Long: -90.62^|
Dakota Access, LLC
core
Translophagy—A potential link between autophagy impairment and translational errors
FEBS Letters, EarlyView.Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk +11 more
wiley +1 more source