Results 121 to 130 of about 12,183,703 (250)
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Dakota Access Pipeline Project, Dakota Access, LLC, mitigation impacts, Iowa & Illinois
Path: \\espsrv\Data\Projects\ETC\80879_DAPL\GIS\DataFiles\ArcDocs\USACE_Meetings\ETC_DAPL_Vicinity_HUC_ACOE.mxd jdringman 4/23/2015 COPYRIGHT© 2015 BURNS & McDONNELL ENGINEERING COMPANY, INC. Rock 10170204 PFO Temp Impacts: 0.22 acres PFO Conversion: .51
Dakota Access, LLC;
core
HIV Research & Clinical PracticeBackground Advances in antiretroviral therapy (ART) have extended the life expectancy of people living with HIV, increasing the prevalence of comorbidities and polypharmacy burden.
Sean P. Fleming +6 more
doaj +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
1300 Miiiii Su-eel Houston, TX 77002 713-989-2000 DAKOTA ACCESS, LLC August 31, 2015 Mr. Mike Carlson Iowa Department of Transportation Water Resources Section - Wetlands Unit 800 Lincoln Way Ames, LA 50010 Re: Dakota Access, LLC Dakota Access Pipeline ...
Dakota Access, LLC;
core
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source