Results 191 to 200 of about 12,183,703 (250)

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

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Public access is not equal access

Science, 2022
On 25 August, the White House Office of Science and Technology Policy provided guidance for scientific publishing aimed at making publications and their supporting data—the products of federally funded research—publicly available without an embargo by the end of 2025.
Sudip, Parikh, Shirley M, Malcom, Bill, Moran   +2 more
openaire   +2 more sources

Accessible accessibility

Proceedings on the 2000 conference on Universal Usability - CUU '00, 2000
This paper discusses the need for an all-encompassing methodology for determining the level of accessibility of web resources, and the requirement that the results of such a procedure are as meaningful as possible to developers. It is argued that current accessibility evaluation methods are unsatisfactory in the scope and presentation of their results.
David Sloan, Peter Gregor, Murray Rowan, Paul Booth   +3 more
openaire   +2 more sources

Accessibility, transcription, and access everywhere

IBM Systems Journal, 2005
Accessibility in the workplace and in academic settings has increased dramatically for users with disabilities, driven by greater awareness, legislative mandate, and technological improvements. Gaps, however, remain. For persons who are deaf and hard of hearing in particular, full participation requires complete access to audio materials, both for live
Keith Bain, Sara H. Basson, Alexander Faisman, Dimitri Kanevsky   +3 more
openaire   +1 more source

Vascular Access for Large Bore Access

Interventional Cardiology Clinics, 2021
Recent advances in the field of interventional cardiology have allowed for more complex procedures to be performed percutaneously. Ability to obtain safe large bore vascular access is frequently the key factor to procedural success. Meticulous technique for successful vascular access incorporates the understanding of anatomic landmarks, ultrasound ...
Stephen, McHugh, Ali, Noory, Suraj, Mishra, Catherine, Vanchiere, Vladimir, Lakhter   +4 more
openaire   +2 more sources

AcceSS

Proceedings of the 2005 International Cross-Disciplinary Workshop on Web Accessibility (W4A) - W4A '05, 2005
The goal of this project is to make the Web more accessible by providing some of the features naturally available to sighted users to users with visual impairments. These features are direct access and gestalt understanding, which can emerge from simplification and summarization. Simplification is achieved by retaining sections of the web page that are
Bambang Parmanto, Reza Ferrydiansyah, Andi Saptono, Lijing Song, I. Wayan Sugiantara, Stephanie Hackett   +5 more
openaire   +2 more sources