Results 71 to 80 of about 1,525,022 (283)

Shared Collection Development, Digitization, and Owned Digital Collections [PDF]

open access: yes, 2019
While library models already exist for sharing physical materials and joint licensing, this paper envisions an aspect of future collections involving a national digital collection owned, not licensed, by libraries.
Wu, Michelle M
core   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

open access: yesFEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman   +2 more
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Access without benefit-sharing: Design, effectiveness and reform of the FAO Seed Treaty

open access: yesInternational Journal of the Commons, 2017
The 2001 International Treaty on Plant Genetic Resources for Food and Agriculture established a global network of seed banks which grants facilitated access to crops for breeding purposes while aiming that the resulting commercial benefits are shared ...
Florian Rabitz
doaj   +1 more source

Access and benefit-sharing policies for climate-resilient seed systems. [PDF]

open access: yes, 2017
The synthesis report is part of a series of papers on Integrated Seed Sector Development (ISSD) in Africa’s thematic working group on Matching national realities with global commitments.
Gapusi, J.   +6 more
core  

Efficient data representation for XML in peer-based systems [PDF]

open access: yes, 2010
Purpose - New directions in the provision of end-user computing experiences mean that the best way to share data between small mobile computing devices needs to be determined.
Christopher, Foley   +3 more
core   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham   +21 more
wiley   +1 more source

Access and Benefit Sharing from the Indigenous Peoples’ Perspective: The TBGRI-Kani ‘Model’ [PDF]

open access: yesLaw, Environment and Development Journal, 2007
The ethno-botanical knowledge of the Kani people related to a plant identified as ‘arogyapacha’ was utilised to develop, transfer, produce and internationally market ‘Jeevani’ as an anti-fatigue, adaptogenic and immuno-enhancing formula by the Tropical ...
C.R. Bijoy
doaj  

Access to genetic resources and benefit-sharing in Colombia: challenges of the legal framework [PDF]

open access: yes, 2016
La investigación analiza los retos que presenta el régimencolombiano sobre acceso a recursos genéticos y distribución debeneficios mediante la utilización del método jurídico, con unenfoque descriptivo, comparativo y propositivo.
Silvestri, Luciana Carla
core   +1 more source

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