Results 91 to 100 of about 1,525,042 (303)

Implications of Uncertainty and Spillovers for Access and Benefit Sharing Agreements [PDF]

One of the objectives of the 1992 Convention on Biological Diversity is to create access to genetic resources and benefit-sharing (ABS) systems that incorporate the environmental, social, and economic aspects of sustainable development.
Ida Ferrara, Paul Missios
core  

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Just and enduring benefit sharing under the Biodiversity Beyond National Jurisdiction (BBNJ) Agreement

Frontiers in Marine Science
Implementing Part II of the Biodiversity Beyond National Jurisdiction (BBNJ) Agreement is an opportunity to transform the global approach to access and benefit sharing (ABS) of biological resources, digital sequence information and traditional knowledge.
Fran Humphries, Fran Humphries
doaj   +1 more source

Potato breeding in the Netherlands: successful collaboration between farmers and commercial breeders. [PDF]

, 2016
Access and benefit sharing of plant genetic resources is a crucial but very complex, political and legalistic matter. Does the formal system work for family farmers?
Almekinders, C., Lammerts van Bueren, E.T., Loon, van, J., Mertens, L.   +3 more
core  

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Implementation of Access and Benefit Sharing in The Bahamas: A Precautionary Tale

Conservation
Biodiversity is incredibly important for the myriad ecosystem services it provides, especially for coastal nations such as The Bahamas. However, the newly implemented access and benefit sharing (ABS) regime is undermining scientific research, which is ...
Krista Sherman, Craig Dahlgren, Charlotte Dunn, Diane Claridge, Nicholas Higgs   +4 more
doaj   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Towards a Fair and Equitable ABS Regime: Is Nagoya Leading us in the Right Direction? [PDF]

Law, Environment and Development Journal, 2013
A historical overview of the concept of Access and Benefit Sharing (ABS) suggests that ABS is all about compensation, i.e. a benefit sharing mechanism that provides one with compensation for allowing access to one’s resources.
Bram De Jonge
doaj  

Mare Geneticum: balancing governance of marine genetic resources in international waters [PDF]

, 2018
A fair and effective regime regulating benefit-sharing of marine genetic resources (MGR) in areas beyond national jurisdiction (ABNJ) must consider the inclusion of developing states, support scientific research and safeguard investments of the private ...
Broggiato, A., Burton, G., Jaspars, M., Lallier, L.E., Muyldermans, D., Vanagt, T.   +5 more
core  

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source