Results 111 to 120 of about 1,525,042 (303)

Factors Determining Transit Access by Car Owners: Implications for Intermodal Passenger Transportation Planning [PDF]

open access: yes, 2013
Although walking is the dominant mode of transportation to transit facilities, there are strong variations by socio-demographics, geography, mode of public transit used and other factors.
Mallon, Y., Thakuriah, P., Tilahun, N.
core  

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

open access: yesMolecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute   +17 more
wiley   +1 more source

Access and Benefit-Sharing Isn’t Equity

open access: yes
It is unsurprising that equity has featured so prominently in the Pandemic Treaty negotiations – the Treaty is a direct response to the COVID-19 pandemic, which was characterised by gross inequality between high-income and LMICs. For all the talk at the start of the Treaty negotiation process of equity, of doing things differently in the future, it ...
openaire   +2 more sources

First mission - towards a global harmonised in-situ data repository for forest biomass datasets validation [PDF]

open access: yes, 2019
Global measurements of forest height, biomass are urgently needed as essential climate and ecosystem variables, but can benefit from greater co-operation between remote sensing (RS) and forest ecological communities.
Chave, J.   +8 more
core   +1 more source

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

open access: yesMolecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg   +43 more
wiley   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

open access: yesMolecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla   +10 more
wiley   +1 more source

The Case for Community Self-Governance on Access and Benefit Sharing of Digital Sequence Information. [PDF]

open access: yesBioscience, 2022
Adler Miserendino RA   +8 more
europepmc   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

open access: yesMolecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala   +15 more
wiley   +1 more source

Agreement on Access and Benefit-sharing for Academic Research: A toolbox for drafting Mutually Agreed Terms for access to Genetic Resources and to Associated Traditional Knowledge and Benefit-sharing [PDF]

open access: yes, 2016
This manual contains a set of model clauses that enables users and providers of genetic resources and associated traditional knowledge to set up a legal contract that is adapted to the individual academic research situation.
Biber-Klemm, Susette   +3 more
core  

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