Factors Determining Transit Access by Car Owners: Implications for Intermodal Passenger Transportation Planning [PDF]
Although walking is the dominant mode of transportation to transit facilities, there are strong variations by socio-demographics, geography, mode of public transit used and other factors.
Mallon, Y., Thakuriah, P., Tilahun, N.
core
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
Critical Review of the Increasing Complexity of Access and Benefit-Sharing Policies of Genetic Resources for Genebank Curators and Plant Breeders-A Public and Private Sector Perspective. [PDF]
Ebert AW +4 more
europepmc +1 more source
Access and Benefit-Sharing Isn’t Equity
It is unsurprising that equity has featured so prominently in the Pandemic Treaty negotiations – the Treaty is a direct response to the COVID-19 pandemic, which was characterised by gross inequality between high-income and LMICs. For all the talk at the start of the Treaty negotiation process of equity, of doing things differently in the future, it ...
openaire +2 more sources
First mission - towards a global harmonised in-situ data repository for forest biomass datasets validation [PDF]
Global measurements of forest height, biomass are urgently needed as essential climate and ecosystem variables, but can benefit from greater co-operation between remote sensing (RS) and forest ecological communities.
Chave, J. +8 more
core +1 more source
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
The Case for Community Self-Governance on Access and Benefit Sharing of Digital Sequence Information. [PDF]
Adler Miserendino RA +8 more
europepmc +1 more source
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Agreement on Access and Benefit-sharing for Academic Research: A toolbox for drafting Mutually Agreed Terms for access to Genetic Resources and to Associated Traditional Knowledge and Benefit-sharing [PDF]
This manual contains a set of model clauses that enables users and providers of genetic resources and associated traditional knowledge to set up a legal contract that is adapted to the individual academic research situation.
Biber-Klemm, Susette +3 more
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