Results 81 to 90 of about 1,525,042 (303)

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source

DISCUS: an end-to-end solution for ubiquitous broadband optical access [PDF]

, 2014
Fiber to the premises has promised to increase the capacity in telecommunications access networks for well over 30 years. While it is widely recognized that optical-fiber-based access networks will be a necessity in the short- to medium-term future, its ...
Achouche, Mohand, Chen, Jiajia, Doran, Nick, Farjady, Farsheed, Montalvo, Julio, O'Sullivan, Barry, Ossieur, Peter, Parsons, Nick, Payne, David B., Pfeiffer, Thomas, Qiu, Xing-Zhi, Raack, Christian, Rohde, Harald, Ruffini, Marco, Schiano, Marco, Townsend, Paul, Wessaly, Roland, Wosinska, Lena, Yin, Xin   +18 more
core   +2 more sources

Gut microbiota diversity is prognostic in metastatic hormone receptor‐positive breast cancer patients receiving chemotherapy and immunotherapy

Molecular Oncology, EarlyView.
In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern, Kristian Holm, Nikolai Kragøe Andresen, Andreas Hagen Røssevold, Corinna Bang, Bjørn Naume, Johannes R. Hov, Jon Amund Kyte   +7 more
wiley   +1 more source

Consumption Risk Sharing over the Business Cycle: the Role of Small Firms' Access to Credit Markets [PDF]

Consumption risk sharing among U.S. federal states increases in booms and decreases in recessions. We find that small firms’ access to credit markets plays an important role in explaining this stylized fact: business cycle fluctuations in aggregate risk ...
Iryna Shcherbakova, Mathias Hoffmann
core  

Biodiversity access and benefit-sharing: weaving a rope of sand [PDF]

, 2011
The Convention on Biological Diversity (CBD)1 is one of the most important treaties in the history of humanity as it deals with the infinitely complex but fragile diversity of life on earth. Regulating access to genetic resources and equitable sharing of
Dharma Rajan, Priyadarsanan, Prathapan, KD   +1 more
core  

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Harmonize rules for digital sequence information benefit-sharing across UN frameworks

Nature Communications
As multiple UN fora develop parallel rules for sharing benefits from digital sequence information, we urge better coordination. International policymakers should focus on harmonizing new benefit-sharing rules to ensure open access to data, database ...
Scarlett Sett, W. John Kress, Michael Halewood, David Nicholson, Genuar Nuñez-Vega, Davide Faggionato, Mathieu Rouard, Marcel Jaspars, Manuela da Silva, Christine Prat, Débora S. Raposo, Irma Klünker, Jens Freitag, Christian Keambou Tiambo, Carolina dos Santos Ribeiro, Linda Wong, Halima Benbouza, Jörg Overmann, DSI Scientific Network signatory authors, Amber Hartman Scholz   +19 more
doaj   +1 more source

Commutative Justice and Access and Benefit Sharing for Genetic Resources [PDF]

Ethics, Policy & Environment, 2018
The Convention on Biological Diversity (CBD) and its Nagoya Protocol (NP) established an Access and Benefit Sharing (ABS) system between utilizers and providers of genetic resources.
openaire   +1 more source