Results 211 to 220 of about 1,506,883 (241)

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Bonobos innovate, plan, and transmit tool use to solve an extractive foraging task. [PDF]

iScience
Zanutto L, Funkhouser JA, Willems EP, Moser A, Sanz C, Clay Z, Koops K.   +6 more
europepmc   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

A DeSci-Driven Blockchain Framework for AI-Augmented Healthcare Research. [PDF]

Blockchain Healthc Today
Singh G, Haroon M, Fatima N, Afsaruddin, Ahmad T, Husain M, Huda M.   +6 more
europepmc   +1 more source

Co-Designing Physical Activity Programmes: A Participatory Research Study With Culturally Diverse Women and Local Government. [PDF]

Health Promot J Austr
Casey M, Porter JE, Eime R.
europepmc   +1 more source

Physicians' Knowledge, Attitudes, and Barriers Toward Clinical Trial Participation in Türkiye: A Cross-Sectional Survey and Implications for Oncology Research Capacity. [PDF]

J Multidiscip Healthc
Kayaalp M, Erdat EC, Ürün Y.
europepmc   +1 more source

Editorial: Aging: challenges and opportunities for inclusion and active participation, volume II. [PDF]

Front Psychol
Aleffi C, Bongelli R, Fermani A, Nicolini P, Guardabassi V.   +4 more
europepmc   +1 more source

Territorial and Farm-Level Inequalities in Cattle Vaccination and Disease-Control Practices in Ecuador: Evidence from the 2025 National Agricultural Survey. [PDF]

Vet Sci
Acosta N, Guarda T.
europepmc   +1 more source

Comment on "Associations of Socioeconomic Status and Group Exercise Participation With Happiness in Older Japanese Adults: A Mediation Analysis". [PDF]

Geriatr Gerontol Int
Liu M.
europepmc   +1 more source