Results 51 to 60 of about 21,971,008 (233)

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Wideband Substrate Integrated Cavity-Backed Dielectric Resonator Antenna at Sub-6-GHz Band

IEEE Open Journal of Antennas and Propagation, 2023
The design and implementation of a wideband single-mode dielectric resonator antenna (DRA) with a substrate integrated cavity-backed structure is presented in this paper.
Reza Shamsaee Malfajani, Jean-Jacques Laurin, Mohammad S. Sharawi   +2 more
doaj   +1 more source

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

Molecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Sarah Reed, Edita Ritmejeryte, Rohan Lourie, Naven Chetty, Kaltin Ferguson, Carlos Salomon   +9 more
wiley   +1 more source

Comparison of different endodontic access cavity designs on the fracture resistance of tooth in waveone gold and trunatomy instrumentation

Journal of Pharmacy and Bioallied Sciences
Background: An important aspect of the preparation of the access cavity and biomechanical preparation of the root canal is to safeguard as much of the tooth's framework as possible without affecting access and visibility.
Mukesh Kumar, Rahul Kumar Rai, Siddharth Shahi, Anshdeep Singh, Nidhi Aggarwal, Fahiem Mohammad Mohammad El-Shamy   +5 more
doaj   +1 more source

The influence of cavity configuration and irrigation activation on root canal smear removal—an in vitro study [PDF]

PeerJ
Background Effective root canal therapy (RCT) depends on proper disinfection rather than complete sterilization of the root canal system. The smear layer created during instrumentation can inhibit disinfection, and its removal is crucial for successful ...
Duygu Degirmencioglu, Şeyda Erşahan, Yelda Erdem Hepsenoglu, Erhan Erkan, Mustafa Gundogar, Kadir Sagir   +5 more
doaj   +2 more sources

Endodontic Management of a Mandibular First Molar with Radix Entomolaris and Conservative Post-endodontic Restoration with CAD/CAM Onlay: A Novel Clinical Technique [PDF]

Journal of Clinical and Diagnostic Research, 2016
This case report describes a novel technique of restoring endodontically treated teeth. Hidden caries causing irreversible pulpitis in a mandibular molar with Radix Entomolaris (RE) was evident.
Kanika Yadav, Ida De Noronha De Ataide, Marina Fernandes, Rajan Lambor, Dalip Alreja   +4 more
doaj   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Effect of access cavity design on canal instrumentation efficiency and fracture resistance in mandibular molars: A cone-beam computed tomography study

Saudi Journal of Oral Sciences
Introduction: This study evaluated the impact of access cavity designs on canal instrumentation efficiency and fracture resistance in mandibular molars using cone-beam computed tomography (CBCT).
Dalia Al-Harith, Rawan Meshal AlOtaibi
doaj   +1 more source

A low-cost, novel endoscopic repeated-access port for small animal research

MethodsX, 2020
Repeated endoscopic access to the abdominal cavity of animal models is useful for a variety of research applications. However, repeated surgical access may affect the welfare of the animal and compromise results.
Shannon N. Ingram, Andrew B. Robbins, Stacy J. Gillenwater, Vince Gresham, James C. Sacchettini, Michael R. Moreno   +5 more
doaj   +1 more source