Results 61 to 70 of about 21,971,008 (233)

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

Structural studies and functional engineering of NanX: an anhydro‐sialic acid transporter from Escherichia coli

FEBS Open Bio, EarlyView.
Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty, Kelsi R. Hall, Zachary D. Tillett, Liam S. Turk, James S. Davies, Michael J. Currie, Hamish G. Brown, Sepideh Valimehr, Peter D. Mace, Andrew E. Whitten, Santosh Panjikar, Eric Hanssen, Rachel A. North, Renwick C.J. Dobson   +13 more
wiley   +1 more source

Structural and biochemical insights into the thermostable esterase Ta0887 from Thermoplasma acidophilum

FEBS Open Bio, EarlyView.
In this study, a novel esterase from the thermoacidophilic archaeon Thermoplasma acidophilum was biochemically and structurally characterized. Our results demonstrate that Ta0887 is a highly thermostable esterase that preferentially hydrolyzes p‐nitrophenyl hexanoate and possesses an α‐helical cap domain that likely contributes to its substrate ...
Alejandro Delgado‐Rey, Miriam Livier Llamas‐García, Gabriela M. Montero‐Morán, Leticia Santos, Samuel Lara‐González   +4 more
wiley   +1 more source

Effects of minimally invasive endodontic access cavity in molar teeth on polymerization, porosity and fracture resistance

Scientific Reports
Minimally invasive access cavities have been proposed in the last decade to reduce tooth tissue loss during endodontic treatment and mitigate compromised fracture resistance of endodontically treated teeth.
Neda Ninkovic, Vanja Opacic Galic, Milos Milosevic, Isaak Trajkovic, Jovana Kuzmanovic Pficer, Danica Bajuk-Bogdanović, Petar Milovanovic, Dilara Yashin El-Bacha, Marija Djuric, Vesna Miletic   +9 more
doaj   +1 more source

Comparative Retreatment Efficacy of Two Multi-File Systems with Different Access Cavity Designs: A Micro-Computed Tomography Study

Medicina
Background and Objectives: The access cavity design and instrumentation system could affect the remaining root canal obturation materials in root canal retreatment.
Emine Odabaşı Tezer, Dilan Kırmızı, Mohamad Abduljalil, Fatma Basmacı, Arda Buyuksungur, Meltem Dartar Öztan   +5 more
doaj   +1 more source

Endodontic guided treatment using augmented reality on a head-mounted display system

Healthcare Technology Letters, 2018
Endodontic treatment is performed to treat inflamed or infected root canal system of any involved teeth. It is estimated that 22.3 million endodontic procedures are performed annually in the USA.
Tianyu Song, Chenglin Yang, Omid Dianat, Ehsan Azimi   +3 more
doaj   +1 more source

Cavity Optomechanics with High Stress Silicon Nitride Films [PDF]

, 2012
There has been a barrage of interest in recent years to marry the fields of nanomechanics and quantum optics. Mechanical systems provide sensitive and scalable architectures for sensing applications ranging from atomic force microscopy to gravity wave ...
Wilson, Dalziel Joseph
core   +1 more source

Characterization of the key membrane protein cytochrome Cyc2 from Ghiorsea bivora

FEBS Open Bio, EarlyView.
This study reports the first detailed biochemical analysis of Cyc2TAG1_1, a cytochrome protein involved in microbial iron oxidation. We produced and purified this enzyme in E. coli, then measured its iron‐oxidizing efficiency, and characterized its electrical and structural properties.
Josiane Azizi, Alain Dolla, Frauke Baymann, Celine Rommevaux, Latifa Elantak, Helene Gaussier, Matthieu Nouailler   +6 more
wiley   +1 more source

Experiments in Cavity QED: Exploring the Interaction of Quantized Light with a Single Trapped Atom [PDF]

, 2005
The experiments discussed in this thesis focus on the interaction of a single trapped atom with the single mode of a high-finesse optical cavity, in the regime of strong coupling.
Boca, Andreea
core   +1 more source