Results 91 to 100 of about 18,416,188 (285)

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Structure identification and state initialization of spin networks with limited access

New Journal of Physics, 2014
For reliable and consistent quantum information processing carried out on a quantum network, the network structure must be fully known and a desired initial state must be accurately prepared on it.
Yuzuru Kato, Naoki Yamamoto
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Preservation of dentin structure with guided versus conventional accesses in calcified canals: In vitro study

Saudi Endodontic Journal
Introduction: Guided endodontic access has emerged as a highly precise approach, utilizing cone beam computed tomography (CBCT) imaging and three-dimensional (3D)-printed guides to navigate calcified canals while minimizing unnecessary dentin removal ...
Marco Quintana, Mauricio Aguirre Balseca, Karina Maria Salvatore Freitas, Maria Soledad Peñaherrera Manosalvas   +3 more
doaj   +1 more source

The use of an improved access structure in dictionaries.

, 2010
: Dictionary consultation procedures often fail because the structure of a dictionary impedes the user from sufficient access to the data. Modern-day metalexicography has identified the access structure as one of the most important structural components ...
R. Gouws
semanticscholar   +1 more source

Nuclear actin structure regulates chromatin accessibility

Nature Communications
AbstractPolymerized β-actin may provide a structural basis for chromatin accessibility and actin transport into the nucleus can guide mesenchymal stem cell (MSC) differentiation. Using MSC, we show that using CK666 to inhibit Arp2/3 directed secondary actin branching results in decreased nuclear actin structure, and significantly alters chromatin ...
Rubin, Janet, Sen, Buer, Xie, Zhihui, Uzer, Gunes, Styner, Maya, Thomas, Michelle D., Howard, Sean, Furey, Terrence S., Pattenden, Samantha G., McGrath, Cody   +9 more
openaire   +3 more sources

Optimal accessing and non-accessing structures for graph protocols

, 2011
An accessing set in a graph is a subset B of vertices such that there exists D subset of B, such that each vertex of V\B has an even number of neighbors in D. In this paper, we introduce new bounds on the minimal size kappa'(G) of an accessing set, and on the maximal size kappa(G) of a non-accessing set of a graph G.
Gravier, Sylvain, Javelle, Jérôme, Mhalla, Mehdi, Perdrix, Simon   +3 more
openaire   +2 more sources

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source