Results 161 to 170 of about 3,120,056 (305)

Out-of-pocket payments, health care access and utilisation in South-Eastern Nigeria : a gender perspective

open access: yes, 2011
Includes abstract.Includes bibliographical references.Out-of-pocket (OOP) payments have severe consequences for health care access and utilisation and are especially catastrophic for the poor.
Onah, Micheal N
core  

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska   +13 more
wiley   +1 more source

Access to Healthcare for Hydrocephalus in the United States: Analyzing the Hydrocephalus Association Patient-Powered Interactive Engagement Registry (HAPPIER)

open access: yesRisk Management and Healthcare Policy
Kevin H Miller,1 Samantha N Lanjewar,1 Noriana E Jakopin,1,2 Amanda Garzon,1 Paul Gross,3 Richard Holubkov,4 Mandeep S Tamber,5 Abhay Moghekar,6 Jason Preston,1 Margaret M Romanoski,7 Chevis N Shannon,8 Tessa van der Willigen,9 Jenna E Koschnitzky,1 ...
Miller KH   +13 more
doaj  

"I've Never Seen It as a Real Problem": Experiences of Access to Care for People Who Use Methamphetamine. [PDF]

open access: yesSubst Abuse Rehabil
Peart A   +6 more
europepmc   +1 more source

Credentials for the infant/toddler child care workforce : a technical assistance tool for child care and development fund administrators.

open access: yes, 2007
Shipping list no.: 2008-0169-P."Administration for Children and Families, Office of Family Assistance, Child Care Bureau, U.S. Dept.
Zero to Three (Organization)   +2 more
core  

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

open access: yesMolecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura   +19 more
wiley   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

open access: yesMolecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober   +16 more
wiley   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

open access: yesMolecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi   +14 more
wiley   +1 more source

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