Results 181 to 190 of about 3,120,056 (305)

Addressing global disparities in neurosurgical workforce and access to care. [PDF]

Chin Neurosurg J
Alokozay E, Haider E, Waseem N, Alokozay N.   +3 more
europepmc   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Supporting Access to Care Through Peripheral Devices and Patient-Generated Health Data: Qualitative Study. [PDF]

J Med Internet Res
Griffin AC, Gray C, Ngo V, Chaudhary C, Shimada SL, Midboe AM, Zulman DM.   +6 more
europepmc   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Emergency Medicaid at Risk - Preserving State Authority and Access to Care. [PDF]

N Engl J Med
Budhu JA, Elshiekh C, Schpero WL, Civelek Y, Au L, Gany FM.   +5 more
europepmc   +1 more source

A New Institutional Economics Perspective on the Relationship Among Societal Values, Governance Structure and Access to Rural Health Care Services

According to New Institutional Economics, transactional activities, governance structures, institutions and beliefs and values are related hierarchally.
James, Harvey S., Jr.
core  

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Navigating healthcare for adults with intellectual disabilities in Singapore: a qualitative study of barriers and facilitators to healthcare system access and care-seeking. [PDF]

BMC Glob Public Health
Chan FJH, Bin Aman MA, Puah LJR, Teo JSH, Chen S, Ali SH, Chan AY, Hildon ZJ.   +7 more
europepmc   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Access to care during COVID-19: A qualitative study of healthcare system resilience in San Antonio, Texas. [PDF]

J Public Health Res
Ovuegbe S, Collier A, Forrest D, McKieran L, Tsai J.   +4 more
europepmc   +1 more source