Results 91 to 100 of about 96,876,350 (295)

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Accessibility to health services by persons with disabilities.

Revista de saude publica, 2011
OBJETIVO: Analizar las dificultades de acceso a los servicios de salud vividas por personas con discapacidad. PROCEDIMIENTOS METODOLÓGICOS: Estudio cualitativo realizado con personas que relataron tener algún tipo de discapacidad (parálisis o amputación de miembros; baja visión, ceguera unilateral o total; baja audición, sordera unilateral o total). Se
Castro, Shamyr Sulyvan, Lefèvre, Fernando, Lefèvre, Ana Maria Cavalcanti, Cesar, Chester Luiz Galvão   +3 more
openaire   +2 more sources

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Physical accessibility and utilization of health services in Yemen. [PDF]

, 2010
BACKGROUND: Assessment of physical access to health services is extremely important for planning. Complex methods that incorporate data inputs from road networks and transport systems are used to assess physical access to healthcare in industrialised ...
Longenecker Joseph C, Abdullah Al-Taiar, Longenecker, Joseph C., Christopher JM Whitty, Al-Taiar Abdullah, Joseph C Longenecker, Al-Taiar, Abdullah, Clark, Allan, Longenecker, Joseph C, Allan Clark, Whitty, Christopher JM, Clark Allan, Whitty, Christopher J. M., Whitty Christopher JM   +13 more
core   +1 more source

HEALTH SERVICE REFORMS AND ACCESS TO SPECIALIST SERVICES [PDF]

Rheumatology, 1991
M A, Chamberlain, A, Tennant
openaire   +2 more sources

Older Adults’ Access to Pharmacological Treatment, a Human Right to Health: Scoping Review (2020–2025)

Pharmacy
Background: Limitations in timely and equitable access to essential medicines among older adults not only constitute a clinical barrier to the effective management of chronic conditions, but also represent a violation of the fundamental right to life ...
Doris Cardona, Valeria Santacruz-Restrepo, Juliana Madrigal-Cadavid, Alejandra Rendón-Montoya, Angela Segura-Cardona, Jorge Iván Estrada-Acevedo, Marcela Agudelo-Botero   +6 more
doaj   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

POVERTY LEVELS MUST BE REDUCED TO IMPROVE ACCESSIBILITY TO HEALTH SERVICES

Jurnal Administrasi Kesehatan Indonesia
Background: Access to health services is a fundamental right for every citizen, but its equitable distribution remains challenging due to the influence of several variables.
Desri Yesi, Ekowati Retnaningsih, Pardomuan Robinson Sihombing, Nuryanto Nuryanto, Irni Novitha   +4 more
doaj   +1 more source