Results 151 to 160 of about 101,683,100 (303)

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Access to information in deaf and hard-of-hearing people. [PDF]

PLoS One
Gutierrez-Sigut E, Lamarche V, Rowley K, Lago EF, Pardo-Guijarro MJ, Saenz I, Frigola B, Frigola S, Aliaga D, Goldberg L.   +9 more
europepmc   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Dakota Access Pipeline Project: Supplemental information to the biological assessment

DAKOTA ACCESS PIPELINE PROJECT SUPPLEMENTAL INEORMATION TO THE BIOLOGICAL ASSESSMENT Dakota Access, EEC April 2016 Description: Dakota Access, EEC (Dakota Access) plans to dewater East Cedar Creek to facilitate open cutting and installation of pipe as ...
Dakota Access, LLC;
core  

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Satisfaction With Internet Access, Cancer Information-Seeking, and Digital Health Technology: Cross-Sectional Survey Assessment. [PDF]

J Med Internet Res
Rincon MA, Moser RP, Blake KD.
europepmc   +1 more source

Access to Information and Degree of Community Awareness of Preventive Health Measures in the Face of COVID-19 in Spain. [PDF]

Healthcare (Basel), 2021
Gutiérrez-Velasco L, Liébana-Presa C, Abella-Santos E, Villar-Suárez V, Fernández-Gutiérrez R, Fernández-Martínez E.   +5 more
europepmc   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Rising Access to Information: Dynamics and Implication

, 2015
Access to information is a fundamental condition for enabling citizens active participation in the modern democratic systems The availability of sufficient required information to citizens makes the accountability of the government possible It is ...
Dr. Azmat Ali Shah, Dr. M. Zubair Khan
core  

"A System That Wasn't Really Optimized for Me": Factors Influencing Autistic University Students' Access to Information. [PDF]

Autism Adulthood
Stockwell KM, Robertson ZS, Lampi AJ, Steinmann T, Morgan E, Jaswal VK.   +5 more
europepmc   +1 more source