Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Preservation of and Access to Government Information and Data: Accounts from the Field
, 2017 Video of the panel session "Preservation of and Access to Government Information and Data: Accounts from the Field" for the 2017 Open Access Symposium with presentations on the End of Term Archive, the US Government Publishing Office, the Data Refuge ...
Laster, Shari +3 more
core
Does mothers' and caregivers' access to information on their child's vaccination card impact the timing of their child's measles vaccination in Uganda? [PDF]
BMC Public Health, 2022 Griffith BC +5 more
europepmc +1 more source
Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding
FEBS Letters, EarlyView.In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança +2 more
wiley +1 more source
Using ELEFIGHT® QR Codes for Quick Access to Information on Influenza Burden and Prevention: A Pilot Study in Lyon University Hospital. [PDF]
Vaccines (Basel), 2022 Khanafer N +17 more
europepmc +1 more source
Translophagy—A potential link between autophagy impairment and translational errors
FEBS Letters, EarlyView.Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk +11 more
wiley +1 more source
Providing Secure Access to Confidential Patient Information Detailing Diabetic Condition [PDF]
, 2001 Can secure access be granted to confidential patient records using the Internet? Our study has involved providing distributed access to one such confidential information database in a United Kingdom (UK) secondary care (hospital) organisation.
McDowell, D.M. +3 more
core
Consumers' access to information about medicine prices and availability as an enabler of last mile medicine access: A scoping review. [PDF]
J Med Access, 2022 Mureyi D, Gwatidzo SD, Matyanga CM.
europepmc +1 more source
FEBS Letters, EarlyView.Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav +2 more
wiley +1 more source