Results 121 to 130 of about 117,175,310 (252)
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Deputies And Access to Public Information
Ius NovumThe article discusses deputies’ information-related rights and obligations. It also analyses administrative courts’ judgments in cases concerning access to public information, in which deputies were requesters or addressees of requests.
Łukasz Nosarzewski
doaj +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
Access to Information, and Concerns, Myths and Truths about Food Safety during the COVID-19 Pandemic: An Overview of the Portuguese Population. [PDF]
Foods, 2023 Lemos M, Maia RL, Teixeira P.
europepmc +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
IFLA Guidelines on Public Internet Access in Libraries
, 2019 IFLA's Guidelines on Public Internet Access in Libraries offer both a firm reiteration of support for the value of such access, but also practical guidance in dealing with the issues that this may raise.
IFLA Freedom of Access to Information and Freedom of Expression (FAIFE) Advisory Committee
core +1 more source
Access to information on gender-based violence prevention during COVID-19 lockdown in Uganda: a cross-sectional study. [PDF]
EClinicalMedicine, 2023 Bukuluki P +10 more
europepmc +1 more source
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Mental Health and Access to Information in Times of COVID-19: The Role of Social Work. [PDF]
Int J Environ Res Public Health, 2022 Romea AC, Valero D, Elboj C, Melgar P.
europepmc +1 more source