Results 111 to 120 of about 117,175,310 (252)

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Access to information and oncofertility consultation for young women with breast cancer: a population-based study. [PDF]

Sci Rep, 2023
Martinet-Kosinski F, Lamy S, Bauvin E, Dalenc F, Vaysse C, Grosclaude P.   +5 more
europepmc   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Open Access to Information. Free Licenses [PDF]

Revista Română de Biblioteconomie și Știința Informării, 2017
In order to clarify perspectives that go beyond the limitations of copyright law, Law no. 8/1996 on copyright and neighbouring rights, we will address below several concepts regarding free licenses, the context in which creative licenses emerged, how to ...
Ionela Maria Bârsan
doaj  

The Factors Associated With Confidence in Using the Internet to Access Health Information: Cross-sectional Data Analysis. [PDF]

JMIR Form Res, 2023
Van Heel KL, Nelson A, Handysides D, Shah H.   +3 more
europepmc   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

A new conceptual and quantitative approach to exploring and defining potential open-access olfactory information. [PDF]

New Phytol, 2022
Orlando CG, Possell M, Price C, Banks PB, Mercorelli L, McArthur C.   +5 more
europepmc   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Meaningful and Inclusive Access to Information

JLIS.it
With the rise of Google and Wikidata as authoritative sources of information for many, with the use of generative Artificial Intelligence, such as Chat GPT, for the creation of new content, and with linked open data as the new, global means of ...
Philip Schreur
doaj   +1 more source

Access to Information and Communication Technology, Digital Skills, and Perceived Well-Being among Older Adults in Hong Kong. [PDF]

Int J Environ Res Public Health, 2023
Fung KK, Hung SS, Lai DWL, Shum MHY, Fung HW, He L.   +5 more
europepmc   +1 more source