Results 91 to 100 of about 12,772,207 (302)

Cell wall target fragment discovery using a low‐cost, minimal fragment library

open access: yesFEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan   +5 more
wiley   +1 more source

Information Access in a Multilingual World: Transitioning from Research to Real-World Applications [PDF]

open access: yes, 2009
Multilingual Information Access (MLIA) is at a turning point wherein substantial real-world applications are being introduced after fifteen years of research into cross-language information retrieval, question answering, statistical machine translation ...
Gey, Fredric   +2 more
core   +2 more sources

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Structural biology of ferritin nanocages

open access: yesFEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Lack of information and access to advanced treatment for Parkinson’s disease patients

open access: yesJournal of Multidisciplinary Healthcare, 2011
J Lökk1,21Department of Neurobiology, Caring Sciences and Society, The Karolinska Institute, 2Karolinska University Hospital Huddinge, Stockholm, SwedenBackground: Parkinson’s disease (PD) patients’ own knowledge and ...
Lökk J
doaj  

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Barriers to Publish in Open Access Journals According to Medical researchers

open access: yesمدیریت اطلاعات سلامت, 2015
Introduction: The Open Access Movement has been one of the best ways that can facilitate information flow. One of the representations of the Open Access Movement is Open Access Journals.
Leila Khalili
doaj  

E-LIS : a step towards redefining Open Access [PDF]

open access: yes, 2006
The past few years have seen tremendous developments in information production, acquisition, and dissemination. Providing access to information free of charge in electronic formats is a concept that is gaining momentum.
Hirwade, Mangala, Mahajan, Kartika
core  

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