Results 71 to 80 of about 5,022,759 (359)

Refining the NaV1.7 pharmacophore of a class of venom‐derived peptide inhibitors via a combination of in silico screening and rational engineering

open access: yesFEBS Letters, EarlyView.
Venom peptides have shown promise in treating pain. Our study uses computer screening to identify a peptide that targets a sodium channel (NaV1.7) linked to chronic pain. We produced the peptide in the laboratory and refined its design, advancing the search for innovative pain therapies.
Gagan Sharma   +8 more
wiley   +1 more source

The power of microRNA regulation—insights into immunity and metabolism

open access: yesFEBS Letters, EarlyView.
MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto   +2 more
wiley   +1 more source

The Open Access Initiative in Access to Technical and Scientific Information in Health Sciences - DOI: 10.3395/reciis.v1i1.50en

open access: yesRECIIS, 2007
The Open Access Initiative (OAI) relates to documents published electronically, and allows free and unrestricted access to the full text of scientific and research literature via the Internet.
Javier Sanz Valero   +2 more
doaj  

Information Access Equality on Network Generative Models [PDF]

open access: yesarXiv, 2021
It is well known that networks generated by common mechanisms such as preferential attachment and homophily can disadvantage the minority group by limiting their ability to establish links with the majority group. This has the effect of limiting minority nodes' access to information.
arxiv  

The Saccharomyces cerevisiae amino acid transporter Lyp1 has a broad substrate spectrum

open access: yesFEBS Letters, EarlyView.
In Saccharomyces cerevisiae, Yeast Amino acid Transporter family members mediate the import of amino acids, ranging from substrate specialists to generalists. Here, we show that the specialist transporter, Lyp1, has a broader substrate spectrum than previously described, with affinity constants spanning from micromolar to millimolar.
Foteini Karapanagioti   +3 more
wiley   +1 more source

THE CONSTITUTIONAL RIGHT TO INFORMATION IN POLAND. THEORY AND PRACTICE

open access: yesInternational Comparative Jurisprudence, 2019
The following article provides the outline of the right to information on activities of the persons discharging public functions and public organs in the Republic of Poland. The article considers the structure of the right established in the Constitution
Michal Bernaczyk
doaj   +1 more source

Information Typology in Coronavirus (COVID-19) Crisis; a Commentary

open access: yesArchives of Academic Emergency Medicine, 2020
Introduction: In late 2019 and early 2020, many people in different countries around the world became infected by the new Coronavirus. This created challenges for these countries in many aspects including economic, political, social, health and so on ...
Hasan Ashrafi-rizi, Zahra Kazempour
doaj   +1 more source

Flow‐based immunomagnetic enrichment of circulating tumor cells from diagnostic leukapheresis product

open access: yesMolecular Oncology, EarlyView.
The number of circulating tumor cells obtained from prostate cancer patients was increased approximately 5‐fold compared to regular CellSearch when processing 2 mL diagnostic leukapheresis material aliquots and increased by 44‐fold when processing 20 mL DLA aliquots using the flow enrichment target capture Halbach‐array.
Michiel Stevens   +8 more
wiley   +1 more source

Evaluation of Internet Information about Lingual Orthodontics Using DISCERN and JAMA Tools

open access: yesTurkish Journal of Orthodontics, 2018
Objective:To investigate the quality and reliability of websites providing information about lingual orthodontics in Turkish.Methods:An internet search was conducted on March 6th, 2017, using popular search engines in Turkey: GoogleTM, bingTM, YAHOO ...
Hatice Kübra Olkun, Arzu Arı Demirkaya
doaj   +1 more source

Unlocking the potential of tumor‐derived DNA in urine for cancer detection: methodological challenges and opportunities

open access: yesMolecular Oncology, EarlyView.
Urine is a rich source of biomarkers for cancer detection. Tumor‐derived material is released into the bloodstream and transported to the urine. Urine can easily be collected from individuals, allowing non‐invasive cancer detection. This review discusses the rationale behind urine‐based cancer detection and its potential for cancer diagnostics ...
Birgit M. M. Wever   +1 more
wiley   +1 more source

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