Results 151 to 160 of about 569,058 (302)

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Access to Medicines for Treating People With Cryptococcal Meningitis. [PDF]

Clin Infect Dis, 2023
Burry J, Casas CP, Ford N.
europepmc   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Access to medicines for children in China. [PDF]

BMJ Paediatr Open, 2022
Chen Z, Li S, Choonara I, Zou K, Zeng L, Huang L, Jia ZJ, Cheng G, Jiang Y, Tang Y, Zhao S, Zhang L.   +11 more
europepmc   +1 more source

Growth in expenditure on high cost drugs in Australia [PDF]

The paper provides an overview of the expenditure of high cost drugs in Australia and examines the average annual growth of these programs. The outlook for expenditure on high cost medicines and possible policy responses is also considered.
Rebecca de Boer, Roy Harvey
core  

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Access to medicines through global health diplomacy. [PDF]

Health Promot Perspect, 2023
Chattu VK, Singh B, Pattanshetty S, Reddy S.   +3 more
europepmc   +1 more source

Early Access to Medicines

Early access to medicines allows the prescription of a medicine before it is available in the public formulary to patients with severe or rare diseases with high unmet needs who have no authorised therapeutic alternatives available. In this context, consistent decision making is difficult, and a systematic assessment procedure could be useful to tackle
Gasol, Montse, Paco, Noelia||, Guarga, Laura||, Bosch Gil, Josep Àngel||, Pontes García, Caridad||, Obach, Mercè||   +5 more
openaire   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Cancer: a looming public health crisis in Africa-a call to accelerate equitable access to medicines. [PDF]

Oncologist
Anorlu RI, Amaeshi LC, Okunade KS, Okunowo AA, Ohazurike EO, Soibi Harry AP, Duru ON, Murphy A.   +7 more
europepmc   +1 more source