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Proportion of Patients in the United States Who Fill Their Nirmatrelvir/Ritonavir Prescriptions

Infectious Diseases and Therapy
Introduction Although real-world studies demonstrate that those prescribed nirmatrelvir/ritonavir (and particularly within 5 days of symptom onset) are less likely to experience severe COVID-19 outcomes, prior studies show that only a small fraction of ...
Abby E. Rudolph, Farid L. Khan, Tanya G. Singh, Srinivas Rao Valluri, Laura A. Puzniak, John M. McLaughlin   +5 more
doaj   +1 more source

How do Recent Population-Level RSVpreF Vaccine-Impact Results from the United Kingdom Relate to Previously Reported Vaccine Effectiveness Results?

Infectious Diseases and Therapy
Introduction Respiratory syncytial virus (RSV) is an important cause of hospitalizations among adults. Following bivalent respiratory syncytial virus prefusion F (RSVpreF) vaccine licensure and implementation, two studies have documented population-level
Negar Aliabadi, Qing Liu, Carmen Hockey, Andrew Vyse, Gillian Ellsbury, Luis Jodar, Elizabeth Begier   +6 more
doaj   +1 more source

Modeling antibody persistence after MenACYW-TT vaccination and comparative analysis with other quadrivalent meningococcal vaccines

Scientific Reports
Evaluating the persistence of antibody titers produced by quadrivalent meningococcal vaccines is crucial for determining the optimal timing for primary and booster doses.
Laurent Coudeville, Isabelle Bertrand-Gerentes, Céline Zocchetti, Edith Langevin, Siham Bchir, Florence Coste, Philipp Oster   +6 more
doaj   +1 more source

Adult RSV Vaccination: What Is the Role of RSV Subgroup in Disease Prevention?

Infectious Diseases and Therapy
Respiratory syncytial virus (RSV) cocirculates as two antigenic subgroups, RSV A and RSV B, with irregular dominance by season. Despite highly conserved fusion (F) protein epitopes, sequence, and antigenic differences between A and B, especially within ...
S. Elizabeth Williams, Giovanni Checcucci Lisi, Kate Luisi, Kumar Ilangovan, Cassandra Hall-Murray, Kyla Hayford, Elizabeth Begier   +6 more
doaj   +1 more source

Generalized Modules for Membrane Antigens (GMMA) Elicit Mild Local Reactogenicity After Intramuscular Injection in Absence of Aluminum Salt Adjuvant

Immunity, Inflammation and Disease
Background and Objectives Generalized modules for membrane antigens (GMMA) are outer membrane vesicles derived from gram‐negative bacteria that can be used to design affordable subunit vaccines.
Raffaella Cecchi, Silvia Maccari, Renzo Alfini, Roberta Di Benedetto, Simona Gallorini, Elena Cartocci, Sara Marchi, Giacomo Romagnoli, Erika Bartolini, Francesca Micoli, Diego Piccioli   +10 more
doaj   +1 more source

Discovery of a small molecule TLR3 agonist adjuvant

Nature Communications
Pattern-recognition receptor (PRR) agonists are valuable agents across multiple medical applications, from vaccinology to immune-oncology. However, well-defined and potent small molecule agonists for many PRRs still await discovery and development ...
Branden Lee, Danica Dong, Etsuro Nanishi, John Mark Awad, Kimia Z. Abedi, Yoshine Saito, Francesco Borriello, Soumik Barman, Byron Brook, Aisling Kelly, Manisha Menon, Constance Marques-Mourlet, Maansi V. Gupta, Ida Lister, Chiwoo Oh, Kevin Lyskawa, Morgan Goetz, Kristina Walker, Wing Ki Cheng, Spencer E. Brightman, Pankaj Sharma, Timothy R. O’Meara, Katherine Chew, Daniel Vieira, Kevin Ryff, Cali Sweitzer, Sanya Thomas, Simon D. van Haren, Matthew Pettengill, Hyuk-Soo Seo, Sirano Dhe-Paganon, Wei Zhang, Ofer Levy, David J. Dowling   +33 more
doaj   +1 more source

Application of Transthoracic Echocardiography for Cardiac Safety Evaluation in the Clinical Development Process of Vaccines Against Streptococcus pyogenes

Drugs in R&D
Superficial infections with Streptococcus pyogenes (Strep A), pharyngitis and impetigo can induce acute rheumatic fever, an autoimmune sequela manifesting mostly with arthritis and rheumatic carditis.
Usman Nakakana, Alimamy Serry-Bangura, Bassey Effiom Edem, Pietro Tessitore, Leonardo Di Cesare, Danilo Gomes Moriel, Audino Podda, Iris Sarah De Ryck, Ashwani Kumar Arora   +8 more
doaj   +1 more source

Establishing long-lasting vaccine immunity: insights from mRNA and adjuvanted protein platforms

npj Vaccines
Durable vaccine-induced immunity is the basis of long-term protection against infection and disease. This review covers three topics. First, we describe the immunological foundations of durable response and its determinants (e.g., vaccine design, host ...
Andrea-Clemencia Pineda-Peña, Kohei Hasegawa, Vincent Pavot, Catherine Berry, Behazine Combadière, Guadalupe Cortes-Garcia, Adrian B. McDermott, Saranya Sridhar   +7 more
doaj   +1 more source

Therapeutic melanoma vaccines: Platforms, neoantigen strategies, and emerging combination immunotherapies. [PDF]

Ther Adv Vaccines Immunother
Mhanna D, Salman B, El Hakim R, Aridi L, Abou Ali W, Al Halabi B, Faour V, Harb F, Azar S, Ghadieh HE.   +9 more
europepmc   +1 more source

Religious beliefs and practices, political orientation, and distrust in healthcare predict attitudes toward mRNA vaccines in the United States. [PDF]

PLOS Glob Public Health
Solomon ED, Chin EG, Baldwin K, Baker LL, DuBois JM.   +4 more
europepmc   +1 more source