Results 21 to 30 of about 493,076 (259)

Causal inference concepts applied to three observational studies in the context of vaccine development: from theory to practice

open access: yesBMC Medical Research Methodology, 2021
Background Randomized controlled trials are considered the gold standard to evaluate causal associations, whereas assessing causality in observational studies is challenging.
Emilia Gvozdenović   +6 more
doaj   +1 more source

To vaccinate or not to vaccinate:

open access: yesStellenbosch Theological Journal, 2022
Faith communities are challenged during the COVID-19 pandemic to urge their members to take a decision to vaccinate or not to vaccinate. The relationship between religion and medical sciences, especially with regard to vaccination, has not always complemented one another, but there is general agreement amongst religions that vaccination is acceptable ...
openaire   +2 more sources

Sequential use of Ad26-based vaccine regimens in NHP to induce immunity against different disease targets

open access: yesnpj Vaccines, 2022
The adenovirus (Ad)26 serotype–based vector vaccine Ad26.COV2.S has been used in millions of subjects for the prevention of COVID-19, but potentially elicits persistent anti-vector immunity.
Selina Khan   +7 more
doaj   +1 more source

Overview of vaccines and vaccination [PDF]

open access: yesMolecular Biotechnology, 2005
Of the 80-plus known infectious agents pathogenic for humans, there are now more than 30 vaccines against 26 mainly viral and bacterial infections and these greatly minimize subsequent disease and prevent death after exposure to those agents. This article describes the nature of the vaccines, from live attenuated agents to subunits, their efficacy and ...
openaire   +3 more sources

Vaccines and Vaccination: The Principles and the Polemics

open access: yesJournal of Feline Medicine and Surgery, 2009
Background The European Advisory Board on Cat Diseases (ABCD) is a body of experts that sees its task as bringing feline health issues to the forefront of companion animal practice. By way of an introduction to this special ‘clinical practice’ issue of the Journal of Feline Medicine and Surgery (JFMS), this article attempts a ...
Horzinek, M. C., Thiry, Etienne
openaire   +3 more sources

From tumor‐centric to ecosystem‐based hypotheses in brain tumor research and care

open access: yesMolecular Oncology, EarlyView.
Primary brain tumors, whether in adults or children, present a major challenge because of their dramatic prognosis and the ongoing lack of efficient therapeutic approaches. In recent years, a shift has occurred from tumor‐centric concepts to a more holistic view of these tumors as dynamic ecosystems.
Julie Gavard   +8 more
wiley   +1 more source

A phase I, randomized, controlled, dose-ranging study of investigational acellular pertussis (aP) and reduced tetanus-diphtheria-acellular pertussis (TdaP) booster vaccines in adults

open access: yesHuman Vaccines & Immunotherapeutics, 2018
Despite high vaccination coverage worldwide, pertussis has re-emerged in many countries. This randomized, controlled, observer-blind phase I study and extension study in Belgium (March 2012–June 2015) assessed safety and immunogenicity of investigational
Geert Leroux-Roels   +22 more
doaj   +1 more source

Cancer cell‐intrinsic type 1 interferon: production, signaling, and outcomes within sex‐biased, female malignancies

open access: yesMolecular Oncology, EarlyView.
The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant   +7 more
wiley   +1 more source

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