Results 161 to 170 of about 522,058 (284)

Early Access to Medicines

Early access to medicines allows the prescription of a medicine before it is available in the public formulary to patients with severe or rare diseases with high unmet needs who have no authorised therapeutic alternatives available. In this context, consistent decision making is difficult, and a systematic assessment procedure could be useful to tackle
Gasol, Montse, Paco, Noelia||, Guarga, Laura||, Bosch Gil, Josep Àngel||, Pontes García, Caridad||, Obach, Mercè||   +5 more
openaire   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

How to balance valuable innovation with affordable access to medicines in Belgium? [PDF]

Front Pharmacol, 2022
Simoens S, Abdallah K, Barbier L, Lacosta TB, Blonda A, Car E, Claessens Z, Desmet T, De Sutter E, Govaerts L, Janssens R, Lalova T, Moorkens E, Saesen R, Schoefs E, Vandenplas Y, Van Overbeeke E, Verbaanderd C, Huys I.   +18 more
europepmc   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Community pharmacists' views about prescription medicine co-payments and potential implications for equitable access to medicines: a critical realist interpretation. [PDF]

J Pharm Policy Pract, 2023
Peacocke EF, Fusheini A, Norris P.
europepmc   +1 more source

International meeting: new diagnostic tests are urgently needed to treat patients with Chaga's disease [PDF]

, 2007
Campaign for Access to Essential Medicines, Medecins Sans Frontieres   +1 more
core   +1 more source

India's product patent protection regime: Less or more of "pills for the poor"? [PDF]

The year 2005 marks the end of transition period for many developing countries with competent pharmaceutical sectors that competed in supplying generic versions of patented drugs to LDCs before, thereby inducing price competition and enhancing access to ...
Gehl Sampath, Padmashree
core  

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

TRIPS flexibilities help change policy and practice to increase access to medicines: evidence from 2001 to 2024. [PDF]

BMJ Glob Health
Dunn M, 't Hoen E, Boulet P, Mara K, Perehudoff K.   +4 more
europepmc   +1 more source

Improving access to medicines and beyond: the national volume-based procurement policy in China. [PDF]

BMJ Glob Health, 2023
Zhu Z, Wang Q, Sun Q, Lexchin J, Yang L.
europepmc   +1 more source