Results 101 to 110 of about 1,855,697 (337)

Hand Dexterity Evaluation Grounded on Cursor Trajectory Investigation in Children with ADHD Using a Mouse and a Joystick

open access: yesTechnologies
This study investigates disparities in upper limb motor skills between children with and without Attention Deficit Hyperactivity Disorder (ADHD), employing one-dimensional (1D) and two-dimensional (2D) point-and-click experiments using a mouse and a ...
Alexandros Pino   +5 more
doaj   +1 more source

Insights into pegRNA design from editing of the cardiomyopathy‐associated phospholamban R14del mutation

open access: yesFEBS Letters, EarlyView.
This study reveals how prime editing guide RNA (pegRNA) secondary structure and reverse transcriptase template length affect prime editing efficiency in correcting the phospholamban R14del cardiomyopathy‐associated mutation. Insights support the design of structurally optimized enhanced pegRNAs for precise gene therapy.
Bing Yao   +7 more
wiley   +1 more source

The heart versus the brain, are they also different when it comes to post-vaccination complications, insights from a systematic review of post-COVID-19 vaccines ADEM cases

open access: yesBulletin of the National Research Centre
Background COVID-19 vaccines have been a game changer in the pandemic, their extensive use was favorable compared to the burden of COVID-19 complications.
Antoine AbdelMassih   +8 more
doaj   +1 more source

Single‐cell insights into the role of T cells in B‐cell malignancies

open access: yesFEBS Letters, EarlyView.
Single‐cell technologies have transformed our understanding of T cell–tumor cell interactions in B‐cell malignancies, revealing new T‐cell subsets, functional states, and immune evasion mechanisms. This Review synthesizes these findings, highlighting the roles of T cells in pathogenesis, progression, and therapy response, and underscoring their ...
Laura Llaó‐Cid
wiley   +1 more source

Strategic Accessibility Competition [PDF]

open access: yes
We analyze the effect of competition in market-accessibility enhancement among quality-differentiated firms. Firms are located in regions with different ex-ante transport costs to reach the final market.
E. Bacchiega, E. Randon, L. Zirulia
core  

Intron‐oriented HTLV‐1 integration in an adult T‐cell leukemia/lymphoma cell line sustains expression of intact ift81 mRNA

open access: yesFEBS Letters, EarlyView.
In the adult T‐cell leukemia/lymphoma (ATL) cell line ED, the human T‐cell leukemia virus type 1 (HTLV‐1) provirus was integrated into the intron of the ift81 gene in the antisense orientation. Despite this integration, both the intact ift81 and the viral oncogene hbz were simultaneously expressed, likely due to the functional insufficiency of viral ...
Mayuko Yagi   +5 more
wiley   +1 more source

Choice and the composition of general practice patient registers [PDF]

open access: yes, 2009
Choice of general practice (GP) in the National Health Service (NHS), the UKs universal healthcare service, is a core element in the current trajectory of NHS policy. This paper uses an accessibility-based approach to investigate the pattern of patient
Lewis, D., Longley, P., Mateos, P.
core  

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