Results 111 to 120 of about 939,166 (317)
High-speed railway developments and corporate location decisions. The role of accessibility [PDF]
Accessibility is a major factor that determines the effects of transport infrastructure developments on corporate location decisions. High-speed railways have an impact on accessibility by reducing travel times and increasing comfort.
Jasper Willigers
core
WADcher: A Unified Web Accessibility Assessment Framework
, 2022 2025This paper presents the architecture of Web Accessibility Directive Decision Support Environment (WADcher), a unified web accessibility assessment framework for large-scale assessment of compliance against web accessibility recommendations and ...
Velasco, Carlos A. +9 more
core
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Travel choices in Scotland - the effect of local accessibility on non-work travel
, 2005 Accessibility features prominently in the developing transport policies of both the United Kingdom Government and the devolved Scottish Executive which aim to promote social inclusion in particular and the integration of transport and land use planning ...
Ferguson, N.S. +2 more
core
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Accessibility and mobile devices
, 2012 A video where Alistair McNaught from TechDIS presents his thoughts on accessibility and the use of mobile devices (run time 10mins 25 secs)
JISC Legal
core
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Brain SciencesObjective: Visual processing deficits arising in dementia are associated with particular functional disability. This study aimed to investigate the effects of the built environment on mobility and navigation in people with dementia-related visual loss ...
Amelia M. Carton +12 more
doaj +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source